PLOD3 and FAM153A

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLOD3	FAM153A
Description		procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	family with sequence similarity 153 member A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Catalytic Activity Iron Ion Binding Protein Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Transferase Activity Glycosyltransferase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Small Molecule Binding Metal Ion Binding Procollagen Galactosyltransferase Activity Dioxygenase Activity	Protein Binding
	Biological Process	In Utero Embryonic Development Endothelial Cell Morphogenesis Protein O-linked Glycosylation Intracellular Protein Localization Peptidyl-lysine Hydroxylation Neural Tube Development Collagen Fibril Organization Collagen Metabolic Process Vasodilation Hydroxylysine Biosynthetic Process Epidermis Morphogenesis Lung Morphogenesis Basement Membrane Assembly
Pathways		Collagen biosynthesis and modifying enzymes
Drugs		Ascorbic acid
Diseases
GWAS		Blood protein levels ( 30072576) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725)	Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: CCDC85B COIL COL17A1 CRIP3 DPPA2 EFHC2 EHMT2 FAM153A IP6K2 KCTD9 KHNYN L3MBTL3 LINC00839 NAB2 RAB3IP RALY RHOU RHOXF2 SORBS3 ZNF620	3 interacting genes: DYNLL1 PLOD3 ROPN1
Entrez ID		8985	285596
HPRD ID		04347	14870
Ensembl ID		ENSG00000106397	ENSG00000170074
Uniprot IDs		O60568	A0A087WYN1 A0A8V8TKN8 A0A8V8TM68 Q9UHL3
PDB IDs		6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE
Enriched GO Terms of Interacting Partners?			Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Hydroxylysine Biosynthetic Process Basement Membrane Assembly Procollagen Galactosyltransferase Activity Procollagen Glucosyltransferase Activity Procollagen-lysine 5-dioxygenase Activity Cilium Organization Epidermis Morphogenesis Nitric-oxide Synthase Regulator Activity Peptidyl-lysine Hydroxylation Microtubule-based Movement Negative Regulation Of DNA-templated DNA Replication Negative Regulation Of Nitric Oxide Biosynthetic Process Intraciliary Retrograde Transport DNA Strand Resection Involved In Replication Fork Processing Endothelial Cell Morphogenesis Protein Hydroxylation Cilium L-ascorbic Acid Binding Sperm Capacitation Cytoplasmic Dynein Complex Small Molecule Binding Negative Regulation Of DNA Replication Lung Morphogenesis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus COP9 Signalosome Dynein Intermediate Chain Binding Substantia Nigra Development Developmental Process Involved In Reproduction Plasma Membrane Bounded Cell Projection Organization Motile Cilium Assembly Dynein Complex Microtubule Associated Complex Microtubule-based Process Aspartate Family Amino Acid Metabolic Process Rough Endoplasmic Reticulum Neural Tube Development Epithelial Cell Morphogenesis Basement Membrane Organization Extracellular Matrix Assembly Ciliary Tip Intraciliary Transport Enzyme Inhibitor Activity Ficolin-1-rich Granule Membrane Neural Nucleus Development Regulation Of Nitric Oxide Metabolic Process Axon Cytoplasm
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