PLOD3 and COL17A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLOD3	COL17A1
Description		procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	collagen type XVII alpha 1 chain
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Extracellular Matrix Extracellular Exosome	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Membrane Hemidesmosome Extracellular Matrix Anchoring Junction
	Molecular Function	Catalytic Activity Iron Ion Binding Protein Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Transferase Activity Glycosyltransferase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Small Molecule Binding Metal Ion Binding Procollagen Galactosyltransferase Activity Dioxygenase Activity	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	In Utero Embryonic Development Endothelial Cell Morphogenesis Protein O-linked Glycosylation Intracellular Protein Localization Peptidyl-lysine Hydroxylation Neural Tube Development Collagen Fibril Organization Collagen Metabolic Process Vasodilation Hydroxylysine Biosynthetic Process Epidermis Morphogenesis Lung Morphogenesis Basement Membrane Assembly	Cell-matrix Adhesion Epidermis Development Hemidesmosome Assembly
Pathways		Collagen biosynthesis and modifying enzymes	Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization
Drugs		Ascorbic acid
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Blood protein levels ( 30072576) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725)	Cardiac hypertrophy ( 21348951)
Interacting Genes		20 interacting genes: CCDC85B COIL COL17A1 CRIP3 DPPA2 EFHC2 EHMT2 FAM153A IP6K2 KCTD9 KHNYN L3MBTL3 LINC00839 NAB2 RAB3IP RALY RHOU RHOXF2 SORBS3 ZNF620	18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN
Entrez ID		8985	1308
HPRD ID		04347	00223
Ensembl ID		ENSG00000106397	ENSG00000065618
Uniprot IDs		O60568	Q9UMD9
PDB IDs		6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE	8IZS
Enriched GO Terms of Interacting Partners?			Cell-substrate Junction Organization Cell-substrate Junction Assembly Anchoring Junction Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Hemidesmosome Cell Junction Organization Cell-cell Adhesion Intermediate Filament Structural Molecule Activity Wound Healing Cell Adhesion Response To Wounding Focal Adhesion Cell Junction Assembly Extracellular Exosome Z Disc Neuregulin Binding Integrin Binding Cadherin Binding Nail Development Fascia Adherens Cytoskeleton Organization Skin Morphogenesis Insulin-like Growth Factor I Binding Stress Fiber Basement Membrane Muscle Cell Development Pseudopodium Cell Periphery Integrin-mediated Signaling Pathway Structural Constituent Of Cytoskeleton Myelination In Peripheral Nervous System Actin Cytoskeleton Integrin Complex Plasma Membrane Cytoskeleton Anatomical Structure Morphogenesis Desmosome Actin Binding Cell-cell Junction Organization Cell Morphogenesis Adherens Junction Negative Regulation Of Blood Vessel Branching Integrin Alpha6-beta4 Complex X11-like Protein Binding Actin Filament Binding Cell Junction Cell-cell Junction
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