HESX1 and PRMT6

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		HESX1	PRMT6
Gene Name		HESX homeobox 1	protein arginine methyltransferase 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Sequence-specific DNA Binding Protein N-terminus Binding	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)
	Biological Process	Transcription, DNA-templated Brain Development Otic Vesicle Formation Nose Development Negative Regulation Of Transcription, DNA-templated Forebrain Morphogenesis	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated
Pathways			Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS			Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		6 interactors: KDM1A NCOR1 NPAS2 PRMT6 PROP1 TLE1	91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		8820	55170
HPRD ID		03482	10505
Ensembl ID			ENSG00000198890
Uniprot IDs		Q9UBX0	Q96LA8
PDB IDs		2K40	4HC4
Enriched GO Terms of Interacting Partners?		Diencephalon Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Central Nervous System Development Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Death Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Pituitary Gland Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Forebrain Development Circadian Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Death RNA Metabolic Process Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Primitive Erythrocyte Differentiation Chromatin Modification Positive Regulation Of Metabolic Process Gene Expression Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone H3-R2 Methylation Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Chromatin Organization Brain Development Head Development Hypophysis Morphogenesis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Circadian Rhythm System Development Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Chromosome Organization Nervous System Development	Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation
Tagcloud ?		affect axis cause deficiency deletions disturbances division encoding failure gh gli2 heterozygous hormone humans labile mutations numerous pericentrin pit1 pituitary pou1f1 prop1 regulators releasing responsible short stat5b stature subunit	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?		affect axis cause deficiency deletions disturbances division encoding failure gh gli2 heterozygous hormone humans labile mutations numerous pericentrin pit1 pituitary pou1f1 prop1 regulators releasing responsible short stat5b stature subunit	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?