HESX1 and CATIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HESX1	CATIP
Description		HESX homeobox 1	ciliogenesis associated TTC17 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Gonad Development Gene Expression Wnt Signaling Pathway Stem Cell Population Maintenance Pituitary Gland Development Thyroid Gland Development Forebrain Development Otic Vesicle Formation Multicellular Organism Growth Camera-type Eye Development Nose Development Negative Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Canonical Wnt Signaling Pathway ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion	Cell Projection Organization Actin Filament Polymerization Cilium Organization
Pathways
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Septo-optic dysplasia
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		12 interacting genes: AIRIM CATIP GUCD1 HOXC8 KDM1A NCOR1 NPAS2 PRMT6 PROP1 STAT3 TLE1 UBL5	15 interacting genes: APP BRD9 CEP72 CTNNBL1 DDIT4L GOLGA6L9 HESX1 KRT31 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 MEDAG MTUS2
Entrez ID		8820	375307
HPRD ID		03482	11846
Ensembl ID		ENSG00000163666	ENSG00000158428
Uniprot IDs		Q9UBX0	Q7Z7H3
PDB IDs		2K40
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of Glycolytic Process Nucleus Negative Regulation Of ATP Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Glycolytic Process Histone H2AR3 Methyltransferase Activity Regulation Of Carbohydrate Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Behavior Hypophysis Morphogenesis Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Intracellular Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Response To CAMP Regulation Of MiRNA Metabolic Process Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Catabolic Process Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Somatotropin Secreting Cell Differentiation RNA Sequestering Activity Protein Demethylase Activity	Keratin Filament Intermediate Filament
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