CDC16

Description		cell division cycle 16
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle
	Molecular Function	Protein Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Novel Interacting Genes		1 novel interacting genes: TUBGCP3
Interacting Genes		22 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B CDC20 CDC23 CDC27 CSTPP1 DAB2 DNAJA1 FTH1 HINT1 LINC00839 MAD2L1 MAPK9 MTNR1B PPP5C SKIL SMAD2 SMAD3 UBE2S XRCC5
Entrez ID		8881
HPRD ID		04587
Ensembl ID		ENSG00000130177
Uniprot IDs		A0A3B3ISD2 B2RCW0 Q13042
PDB IDs		3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Sister Chromatid Separation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Meiotic Cell Cycle Regulation Of Chromosome Segregation Regulation Of Chromosome Organization Regulation Of Chromosome Separation Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Positive Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Checkpoint Complex Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Positive Regulation Of Chromosome Separation Proteasomal Protein Catabolic Process Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Nuclear Division Cytosol Protein Catabolic Process Regulation Of Organelle Organization Mitotic Cell Cycle Phase Transition Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Paraxial Mesoderm Morphogenesis Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Protein Ubiquitination Proteolysis Spindle Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition
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