CDC16 and HINT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CDC16	HINT1
Description		cell division cycle 16	histidine triad nucleotide binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Catalytic Activity Protein Kinase C Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity Adenosine 5'-monophosphoramidase Activity
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Regulation Of DNA-templated Transcription Proteolysis Apoptotic Process Signal Transduction Purine Ribonucleotide Catabolic Process Protein Desumoylation Positive Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Adenosine phosphate Guanosine-5'-Monophosphate 5'-O-(N-Ethyl-Sulfamoyl)Adenosine Adenosine-5'-ditungstate 8-Bromo-Adenosine-5'-Monophosphate
Diseases
GWAS		Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		22 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B CDC20 CDC23 CDC27 CSTPP1 DAB2 DNAJA1 FTH1 HINT1 LINC00839 MAD2L1 MAPK9 MTNR1B PPP5C SKIL SMAD2 SMAD3 UBE2S XRCC5	9 interacting genes: CDC16 CPSF7 ERBB3 MITF RGS17 RGS19 SP1 TRIM29 USP40
Entrez ID		8881	3094
HPRD ID		04587	03204
Ensembl ID		ENSG00000130177	ENSG00000169567
Uniprot IDs		A0A3B3ISD2 B2RCW0 Q13042	A0A384NPU2 D6RD60 P49773
PDB IDs		3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	1AV5 1KPA 1KPB 1KPC 1KPE 1KPF 3TW2 4EQE 4EQG 4EQH 4ZKL 4ZKV 5ED3 5ED6 5EMT 5I2E 5I2F 5IPB 5IPC 5IPD 5IPE 5KLY 5KLZ 5KM0 5KM1 5KM2 5KM3 5KM4 5KM6 5KMA 5KMB 5KMC 5O8I 5WA8 5WA9 5WAA 6B42 6G9Z 6J53 6J58 6J5S 6J5Z 6J64 6J65 6N3V 6N3W 6N3X 6N3Y 6YQM 7Q2U 8P8P 8PA6 8PA9 8PAF 8PAI 8PWK 8WZD
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Sister Chromatid Separation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Meiotic Cell Cycle Regulation Of Chromosome Segregation Regulation Of Chromosome Organization Regulation Of Chromosome Separation Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Positive Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Checkpoint Complex Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Positive Regulation Of Chromosome Separation Proteasomal Protein Catabolic Process Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Nuclear Division Cytosol Protein Catabolic Process Regulation Of Organelle Organization Mitotic Cell Cycle Phase Transition Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Paraxial Mesoderm Morphogenesis Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Protein Ubiquitination Proteolysis Spindle Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition
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