CDC16 and C11orf49

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDC16	C11orf49
Gene Name		cell division cycle 16	chromosome 11 open reading frame 49
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule	Nucleoplasm
	Molecular Function	Protein Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS			D-dimer levels ( 21502573)
Protein-Protein Interactions		22 interactors: ANAPC10 ANAPC11 ANAPC7 BUB1B C11orf49 CDC20 CDC23 CDC26 CDC27 CDH1 DAB2 DNAJA1 FBXO5 FTH1 HINT1 MAD2L1 PPP5C SKIL SMAD2 SMAD3 UBE2S XRCC5	12 interactors: ARHGEF15 CDC16 GSR PNMA5 PSMA1 RAB17 RAB29 RBM48 RPL8 RPS3A UBE3A UBQLN4
Entrez ID		8881	79096
HPRD ID		04587	08332
Ensembl ID		ENSG00000130177	ENSG00000149179
Uniprot IDs		Q13042	B4DUV7 Q9H6J7
PDB IDs		3HYM
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Mitotic Spindle Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Segregation Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ligase Activity Protein K11-linked Ubiquitination Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Cell Cycle Process Cell Division Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle	Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Polyubiquitination Viral Process Regulation Of Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Rab Protein Signal Transduction Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cellular Pigmentation Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Sperm Entry Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Ubiquitin-protein Transferase Activity Catabolic Process Viral Transcription Regulation Of Synapse Structure Or Activity Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Negative Regulation Of Synapse Maturation Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Cotranslational Protein Targeting To Membrane Protein Targeting To ER Negative Regulation Of Protein Ubiquitination Establishment Of Protein Localization To Endoplasmic Reticulum Pigmentation Ubiquitin-dependent Protein Catabolic Process Retrograde Transport, Plasma Membrane To Golgi Modification-dependent Protein Catabolic Process Protein Localization To Endoplasmic Reticulum Positive Regulation Of Protein Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Immunoglobulin Transcytosis In Epithelial Cells Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Translational Termination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Ubiquitination Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process MRNA Catabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process
Tagcloud ?		2a akt anabolic bub2 coimmunoprecipitated constant dephosphorylation homolog mechanistic modulator mtorc1 nutrients phosphorylates pp2a rapamycin redd1 repress represses repressor rheb ser stimulating tbc1d7 thr tre2 tsc tsc1 tsc2 tuberous
Tagcloud (Difference) ?		2a akt anabolic bub2 coimmunoprecipitated constant dephosphorylation homolog mechanistic modulator mtorc1 nutrients phosphorylates pp2a rapamycin redd1 repress represses repressor rheb ser stimulating tbc1d7 thr tre2 tsc tsc1 tsc2 tuberous
Tagcloud (Intersection) ?