CDC16 and FTH1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDC16	FTH1
Gene Name		cell division cycle 16	ferritin, heavy polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule	Nucleus Mitochondrion Cytosol Intracellular Ferritin Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Ferroxidase Activity Iron Ion Binding Protein Binding Ferric Iron Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Immune Response Negative Regulation Of Cell Proliferation Negative Regulation Of Fibroblast Proliferation Transmembrane Transport Oxidation-reduction Process Membrane Organization
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System	Iron uptake and transport Golgi Associated Vesicle Biogenesis Scavenging by Class A Receptors trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs			Iron Dextran
Diseases
GWAS			Estradiol levels ( 22675492) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		22 interactors: ANAPC10 ANAPC11 ANAPC7 BUB1B C11orf49 CDC20 CDC23 CDC26 CDC27 CDH1 DAB2 DNAJA1 FBXO5 FTH1 HINT1 MAD2L1 PPP5C SKIL SMAD2 SMAD3 UBE2S XRCC5	31 interactors: BRD7 CD99 CDC16 CDC25A CRMP1 CSF3R CSNK2B DAXX ELL3 FTL FXR2 GOLM1 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 PACSIN1 PIAS4 SDCBP SOX5 SPP1 TICAM2 TOLLIP TRAF4 UBR1 WDYHV1 YWHAE
Entrez ID		8881	2495
HPRD ID		04587	00615
Ensembl ID		ENSG00000130177	ENSG00000167996
Uniprot IDs		Q13042	P02794
PDB IDs		3HYM	1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Mitotic Spindle Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Segregation Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ligase Activity Protein K11-linked Ubiquitination Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Cell Cycle Process Cell Division Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle	Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Metabolic Process Chemotaxis Positive Regulation Of Signal Transduction Hormone-mediated Signaling Pathway Response To Stimulus Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cell Communication Regulation Of Protein Metabolic Process System Development Movement Of Cell Or Subcellular Component Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Generation Of Neurons Anatomical Structure Development Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Toll-like Receptor Signaling Pathway Locomotion Positive Regulation Of Protein Sumoylation Signaling Response To Hormone Neurogenesis Cellular Response To Lipid Leukocyte Migration Signal Transduction Regulation Of Signaling Steroid Hormone Mediated Signaling Pathway Multicellular Organismal Development Regulation Of Protein Sumoylation Response To External Stimulus Leukocyte Chemotaxis Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of JNK Cascade Cell Migration Response To Lipid Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Transcription From RNA Polymerase II Promoter Cell Motility Negative Regulation Of Gene Expression
Tagcloud ?		2a akt anabolic bub2 coimmunoprecipitated constant dephosphorylation homolog mechanistic modulator mtorc1 nutrients phosphorylates pp2a rapamycin redd1 repress represses repressor rheb ser stimulating tbc1d7 thr tre2 tsc tsc1 tsc2 tuberous	aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Difference) ?		2a akt anabolic bub2 coimmunoprecipitated constant dephosphorylation homolog mechanistic modulator mtorc1 nutrients phosphorylates pp2a rapamycin redd1 repress represses repressor rheb ser stimulating tbc1d7 thr tre2 tsc tsc1 tsc2 tuberous	aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
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