CRKL and AOX1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CRKL	AOX1
Gene Name		v-crk avian sarcoma virus CT10 oncogene homolog-like	aldehyde oxidase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Cytosol Extracellular Vesicular Exosome	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding	Aldehyde Oxidase Activity Xanthine Dehydrogenase Activity Iron Ion Binding UDP-N-acetylmuramate Dehydrogenase Activity Electron Carrier Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding NAD Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Inflammatory Response Vitamin B6 Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Reactive Oxygen Species Metabolic Process
Pathways		Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Vitamins B6 activation to pyridoxal phosphate Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS			Intelligence ( 22449649)
Protein-Protein Interactions		71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1	5 interactors: ABCA1 CRKL GK RBL1 RCHY1
Entrez ID		1399	316
HPRD ID		03596	07537
Ensembl ID		ENSG00000099942	ENSG00000138356
Uniprot IDs		P46109	B4DNI5 Q06278
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process	Glycerol-3-phosphate Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Interleukin-1 Beta Secretion Glycerol Catabolic Process Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Positive Regulation Of Metabolic Process Alcohol Metabolic Process Parathyroid Gland Development Platelet Dense Granule Organization Regulation Of Phosphorus Metabolic Process Phospholipid Efflux Glycerol-3-phosphate Metabolic Process Phagocytosis, Engulfment Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Cellular Response To Cholesterol Negative Regulation Of Macrophage Derived Foam Cell Differentiation Reverse Cholesterol Transport Response To Laminar Fluid Shear Stress Membrane Invagination Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Cellular Response To Organic Substance Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cdc42 Protein Signal Transduction Cellular Carbohydrate Catabolic Process Glycerol Metabolic Process Cytokine Secretion Response To Fluid Shear Stress Regulation Of Cholesterol Transport Secretory Granule Organization Protein Autoubiquitination Triglyceride Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Anion Homeostasis
Tagcloud ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	autophagosomes backgroundthe compromised conclusionshigh cultivation eliminated factory g3 glycosylation heterologous immature inverted leakage mark methanol pastoris pichia popular processed prolonged quickly resultsa retention rhil rhil10 shortened unfolded varies yield
Tagcloud (Difference) ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	autophagosomes backgroundthe compromised conclusionshigh cultivation eliminated factory g3 glycosylation heterologous immature inverted leakage mark methanol pastoris pichia popular processed prolonged quickly resultsa retention rhil rhil10 shortened unfolded varies yield
Tagcloud (Intersection) ?