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CRKL and POLR1D
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
CRKL
POLR1D
Description
CRK like proto-oncogene, adaptor protein
RNA polymerase I and III subunit D
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Synapse
Extrinsic Component Of Postsynaptic Membrane
DNA-directed RNA Polymerase Complex
Nucleus
Nucleoplasm
RNA Polymerase III Complex
Nucleolus
RNA Polymerase I Complex
Cytosol
Nuclear DNA-directed RNA Polymerase Complex
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Receptor Tyrosine Kinase Binding
Signaling Adaptor Activity
Identical Protein Binding
Cadherin Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA Binding
DNA-directed RNA Polymerase Activity
Protein Binding
Protein Dimerization Activity
Biological Process
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Regulation Of Leukocyte Migration
Outflow Tract Morphogenesis
Lipid Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Pattern Specification Process
Heart Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Animal Organ Morphogenesis
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Migration
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Rac Protein Signal Transduction
Intracellular Signal Transduction
Helper T Cell Diapedesis
Reelin-mediated Signaling Pathway
Positive Regulation Of MAPK Cascade
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Negative Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Fibroblast Growth Factor
Endothelin Receptor Signaling Pathway
Acetylcholine Receptor Signaling Pathway
Postsynaptic Specialization Assembly
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Chordate Pharynx Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
DNA-templated Transcription
Transcription Elongation By RNA Polymerase I
Transcription By RNA Polymerase III
Pathways
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Cytosolic sensors of pathogen-associated DNA
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
Treacher Collins syndrome
GWAS
Mean platelet volume (
32888494
)
Platelet distribution width (
27863252
32888494
)
Body mass index (
26426971
)
Interacting Genes
78 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
15 interacting genes:
CDC25A
CEBPA
CRKL
DDIT3
DNAJB4
DNAJB6
E2F4
GRB2
HAX1
MAGEA11
MRPL12
NFKBIB
NR3C1
POLR1C
PXN
Entrez ID
1399
51082
HPRD ID
03596
17877
Ensembl ID
ENSG00000099942
ENSG00000186184
Uniprot IDs
P46109
A0A087WTY1
P0DPB5
P0DPB6
PDB IDs
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
7A6H
7AE1
7AE3
7AEA
7AST
7D58
7D59
7DN3
7DU2
7FJI
7FJJ
7OB9
7OBA
7OBB
7VBA
7VBB
7VBC
8A43
8ITY
8IUE
8IUH
9FSO
9FSP
9FSQ
9FSR
9FSS
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
SH3 Domain Binding
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Protein Tyrosine Kinase Activity
Immune System Process
Insulin Receptor Signaling Pathway
Cell Activation
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Leukocyte Activation
Immune Effector Process
ERBB Signaling Pathway
B Cell Receptor Signaling Pathway
Lymphocyte Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signaling Cassette
Cytosol
Regulation Of Immune System Process
B Cell Differentiation
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
B Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Positive Regulation Of MAPK Cascade
Cell Migration
Cellular Response To Growth Factor Stimulus
Plasma Membrane
Regulation Of Cell Activation
Immune Response-regulating Signaling Pathway
Protein Tyrosine Kinase Binding
Positive Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Protein Kinase Activity
Positive Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Growth Hormone Receptor Signaling Pathway
T Cell Activation
Regulation Of Signaling
Regulation Of Cell Communication
Response To Growth Factor
Regulation Of Multicellular Organismal Development
Ephrin Receptor Binding
Regulation Of Leukocyte Proliferation
CHOP-C/EBP Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Transcription Regulator Complex
Regulation Of DNA-templated Transcription
Protein Domain Specific Binding
Regulation Of RNA Biosynthetic Process
Protein-folding Chaperone Binding
Transcription By RNA Polymerase I
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Transcription Regulator Complex
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
ATPase Activator Activity
Nucleoplasm
Cytoplasm
Regulation Of Primary Metabolic Process
DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Cortex
Integrated Stress Response Signaling
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Response To Dexamethasone
Macrophage Differentiation
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Phosphotyrosine Residue Binding
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
Guanyl-nucleotide Exchange Factor Adaptor Activity
Nuclear Glucocorticoid Receptor Activity
Macromolecule Biosynthetic Process
Cytosol
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Xenobiotic Stimulus
Gland Development
Negative Regulation Of Biosynthetic Process
Response To Vitamin B2
C/EBP Complex
Helper T Cell Diapedesis
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Tagcloud (Intersection)
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