CRKL and ARHGAP32

Number of citations of the paper that reports this interaction (PubMedID 12446789)
62

Data Source:
HPRD (in vivo)

		CRKL	ARHGAP32
Description		CRK like proto-oncogene, adaptor protein	Rho GTPase activating protein 32
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Neuromuscular Junction Protein-containing Complex Synapse Extrinsic Component Of Postsynaptic Membrane	Golgi Membrane Fibrillar Center Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Membrane Cell Projection Dendritic Spine Synapse
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Identical Protein Binding Cadherin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Regulation Of Leukocyte Migration Outflow Tract Morphogenesis Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Pattern Specification Process Heart Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Animal Organ Morphogenesis Anterior/posterior Pattern Specification Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Helper T Cell Diapedesis Reelin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Fibroblast Growth Factor Endothelin Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Specialization Assembly Cerebellar Neuron Development Cellular Response To Interleukin-7 Chordate Pharynx Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet distribution width ( 27863252 32888494)	Intracranial aneurysm ( 30823506) Iris color (L* coordinate) ( 29109912) Macular thickness ( 30535121) Metabolite levels (5-HIAA) ( 23319000) Refractive error ( 32231278)
Interacting Genes		78 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1	33 interacting genes: ABI2 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LHX2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC TLE5
Entrez ID		1399	9743
HPRD ID		03596	12257
Ensembl ID		ENSG00000099942	ENSG00000134909
Uniprot IDs		P46109	A0A804HK06 A7KAX9
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW	3IUG
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction SH3 Domain Binding Phosphotyrosine Residue Binding Intracellular Signal Transduction Protein Tyrosine Kinase Activity Immune System Process Insulin Receptor Signaling Pathway Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Leukocyte Activation Immune Effector Process ERBB Signaling Pathway B Cell Receptor Signaling Pathway Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Cytosol Regulation Of Immune System Process B Cell Differentiation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Growth Factor Stimulus Plasma Membrane Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Binding Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway T Cell Activation Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Regulation Of Multicellular Organismal Development Ephrin Receptor Binding Regulation Of Leukocyte Proliferation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Migration Cell Surface Receptor Signaling Pathway Cell Motility Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Signal Transduction Cell-cell Junction Ephrin Receptor Signaling Pathway Regulation Of Signal Transduction Developmental Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Biogenesis Ephrin Receptor Binding Lamellipodium Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Protein Kinase Binding Signaling Adaptor Activity Neuron Migration Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Actin Filament Organization Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Regulation Of Locomotion Cell-cell Junction Organization Regulation Of Lamellipodium Organization Cell Projection Organization
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