CRKL and MAP4K5

Number of citations of the paper that reports this interaction (PubMedID 10648385)
0

Data Source:
HPRD (in vivo, in vitro)

		CRKL	MAP4K5
Description		CRK like proto-oncogene, adaptor protein	mitogen-activated protein kinase kinase kinase kinase 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Neuromuscular Junction Protein-containing Complex Synapse Extrinsic Component Of Postsynaptic Membrane	Cytoplasm Cytosol Plasma Membrane Cilium
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Identical Protein Binding Cadherin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Regulation Of Leukocyte Migration Outflow Tract Morphogenesis Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Pattern Specification Process Heart Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Animal Organ Morphogenesis Anterior/posterior Pattern Specification Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Helper T Cell Diapedesis Reelin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Fibroblast Growth Factor Endothelin Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Specialization Assembly Cerebellar Neuron Development Cellular Response To Interleukin-7 Chordate Pharynx Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration	MAPK Cascade Intracellular Signal Transduction
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs			Fostamatinib
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet distribution width ( 27863252 32888494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Red blood cell count ( 32888494)
Interacting Genes		78 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1	13 interacting genes: ABL1 BCR COPS5 CRK CRKL GRB2 HCK NEDD4 SETDB1 SMURF1 TANK TRAF2 ZNF440
Entrez ID		1399	11183
HPRD ID		03596	05374
Ensembl ID		ENSG00000099942	ENSG00000012983
Uniprot IDs		P46109	B3KWC4 Q9Y4K4
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction SH3 Domain Binding Phosphotyrosine Residue Binding Intracellular Signal Transduction Protein Tyrosine Kinase Activity Immune System Process Insulin Receptor Signaling Pathway Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Leukocyte Activation Immune Effector Process ERBB Signaling Pathway B Cell Receptor Signaling Pathway Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Cytosol Regulation Of Immune System Process B Cell Differentiation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Growth Factor Stimulus Plasma Membrane Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Binding Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway T Cell Activation Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Regulation Of Multicellular Organismal Development Ephrin Receptor Binding Regulation Of Leukocyte Proliferation	Phosphotyrosine Residue Binding Protein-containing Complex Regulation Of Dendrite Development Helper T Cell Diapedesis Regulation Of Cellular Component Organization Ephrin Receptor Binding Response To External Biotic Stimulus Cerebellar Neuron Development Regulation Of Immune Response Regulation Of Mononuclear Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Plasma Membrane Bounded Cell Projection Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Regulation Of T Cell Migration Regulation Of Metabolic Process Enzyme Binding Diapedesis Regulation Of Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neuron Projection Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Regulation Of Lymphocyte Migration Negative Regulation Of Immune Response Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Response To Transforming Growth Factor Beta Regulation Of Leukocyte Migration Protein Domain Specific Binding Leukocyte Migration Regulation Of Anatomical Structure Morphogenesis Immune System Process Signaling Adaptor Activity Postsynaptic Specialization Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Cytosol Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Nitric Oxide
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