KHSRP and PTBP2

Number of citations of the paper that reports this interaction (PMID 11003644)
108

Data Source:
BioGRID (pull down)

		KHSRP	PTBP2
Gene Name		KH-type splicing regulatory protein	polypyrimidine tract binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cytoplasmic Stress Granule Membrane	Spliceosomal Complex
	Molecular Function	DNA Binding MRNA Binding Poly(A) RNA Binding	Nucleotide Binding MRNA Binding Poly(A) RNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Processing MRNA Catabolic Process RNA Splicing Gene Expression MRNA Transport Regulation Of MiRNA Metabolic Process	MRNA Splice Site Selection Negative Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			Body mass index ( 20935630) Schizophrenia ( 19571811 22688191)
Protein-Protein Interactions		12 interactors: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 PARN PTBP2 STK3	17 interactors: CALCOCO2 EIF5A2 ELAVL1 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 SNRPA TOM1
Entrez ID		8570	58155
HPRD ID		10350	12233
Ensembl ID		ENSG00000088247	ENSG00000117569
Uniprot IDs		Q92945	Q9UKA9
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	2CQ1
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Processing Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Localization Nitrogen Compound Metabolic Process MRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process SnoRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance RRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process Maturation Of 5.8S RRNA Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process Gene Expression MRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process SnRNA Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death SnRNA Metabolic Process Regulation Of Growth Positive Regulation Of Cell Death MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Positive Regulation Of Protein Binding Negative Regulation Of Thymidylate Synthase Biosynthetic Process	MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Gene Expression Positive Regulation Of Translation RNA Metabolic Process Circadian Regulation Of Translation RNA Splicing, Via Transesterification Reactions 3'-UTR-mediated MRNA Stabilization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process MRNA Transport RNA Transport RNA Localization Nitrogen Compound Metabolic Process MRNA Stabilization Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Polyamine Homeostasis Regulation Of Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of RNA Export From Nucleus 3'-UTR-mediated MRNA Destabilization Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process IRES-dependent Translational Initiation Cap-independent Translational Initiation Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Spermatogenesis Male Gamete Generation MRNA Destabilization Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Translation In Response To Stress Circadian Rhythm Macromolecule Biosynthetic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA
Tagcloud ?		apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation	17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways
Tagcloud (Difference) ?		apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation	17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways
Tagcloud (Intersection) ?