PTBP2 and ELAVL1

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		PTBP2	ELAVL1
Gene Name		polypyrimidine tract binding protein 2	ELAV like RNA binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Nucleotide Binding MRNA Binding Poly(A) RNA Binding	Nucleotide Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding AU-rich Element Binding Protein Kinase Binding MRNA 3'-UTR AU-rich Region Binding Poly(A) RNA Binding
	Biological Process	MRNA Splice Site Selection Negative Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	Multicellular Organismal Development Gene Expression Positive Regulation Of Translation MRNA Stabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Maintenance
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements HuR stabilizes mRNA
Drugs
Diseases
GWAS		Body mass index ( 20935630) Schizophrenia ( 19571811 22688191)
Protein-Protein Interactions		17 interactors: CALCOCO2 EIF5A2 ELAVL1 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 SNRPA TOM1	35 interactors: ANP32A ANP32B APOE CARM1 CELF2 CHEK2 CTNNB1 ERG GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP1 PTBP2 PTGS2 RBFOX2 SDCBP SET SREK1 TNPO1 TNPO2 VEGFA XIAP
Entrez ID		58155	1994
HPRD ID		12233	16025
Ensembl ID		ENSG00000117569	ENSG00000066044
Uniprot IDs		Q9UKA9	B4DVB8 Q15717
PDB IDs		2CQ1	3HI9 4ED5 4EGL 4FXV
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Gene Expression Positive Regulation Of Translation RNA Metabolic Process Circadian Regulation Of Translation RNA Splicing, Via Transesterification Reactions 3'-UTR-mediated MRNA Stabilization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process MRNA Transport RNA Transport RNA Localization Nitrogen Compound Metabolic Process MRNA Stabilization Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Polyamine Homeostasis Regulation Of Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of RNA Export From Nucleus 3'-UTR-mediated MRNA Destabilization Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process IRES-dependent Translational Initiation Cap-independent Translational Initiation Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Spermatogenesis Male Gamete Generation MRNA Destabilization Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Translation In Response To Stress Circadian Rhythm Macromolecule Biosynthetic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA See more	Regulation Of Wound Healing Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Positive Regulation Of Transport Negative Regulation Of Wound Healing Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Negative Regulation Of Cellular Protein Metabolic Process Cell Death Death Regulation Of Platelet Activation Regulation Of Metabolic Process Cell Communication Signal Transduction Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Ion Transport Regulation Of Nitrogen Compound Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Receptor Activity Signaling Response To Abiotic Stimulus Blood Coagulation Negative Regulation Of Platelet Activation Hemostasis Regulation Of Epithelial Cell Migration Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Stimulus Regulation Of Apoptotic Process Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Organic Substance Regulation Of Cell Death Response To Wounding Blood Circulation Response To Cytokine Execution Phase Of Apoptosis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial Cell Migration Vasculature Development RNA Splicing Regulation Of Peptidyl-tyrosine Phosphorylation See more
Tagcloud ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	bace1 bingo cdk2 clustering criterion cytoscape degs downloaded glioma gse31262 hierarchical kif23 kobas language limma log2fc mbp multtest myelination omnibus ontology package pheatmap plp1 plug software string webgestalt wee1
Tagcloud (Difference) ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	bace1 bingo cdk2 clustering criterion cytoscape degs downloaded glioma gse31262 hierarchical kif23 kobas language limma log2fc mbp multtest myelination omnibus ontology package pheatmap plp1 plug software string webgestalt wee1
Tagcloud (Intersection) ?