PTBP2 and EIF5A2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PTBP2	EIF5A2
Gene Name		polypyrimidine tract binding protein 2	eukaryotic translation initiation factor 5A2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex	Nuclear Pore Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	Nucleotide Binding MRNA Binding Poly(A) RNA Binding	Translation Elongation Factor Activity Protein Binding Ribosome Binding
	Biological Process	MRNA Splice Site Selection Negative Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	Translational Frameshifting Spermatogenesis Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Polyamine Homeostasis Protein Transport Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination MRNA Transport
Pathways			Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs
Diseases
GWAS		Body mass index ( 20935630) Schizophrenia ( 19571811 22688191)
Protein-Protein Interactions		17 interactors: CALCOCO2 EIF5A2 ELAVL1 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 SNRPA TOM1	7 interactors: CDC23 DHPS NIF3L1 PTBP2 RAB30 REL SDCBP
Entrez ID		58155	56648
HPRD ID		12233	10426
Ensembl ID		ENSG00000117569	ENSG00000163577
Uniprot IDs		Q9UKA9	Q9GZV4
PDB IDs		2CQ1
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Gene Expression Positive Regulation Of Translation RNA Metabolic Process Circadian Regulation Of Translation RNA Splicing, Via Transesterification Reactions 3'-UTR-mediated MRNA Stabilization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process MRNA Transport RNA Transport RNA Localization Nitrogen Compound Metabolic Process MRNA Stabilization Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Polyamine Homeostasis Regulation Of Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of RNA Export From Nucleus 3'-UTR-mediated MRNA Destabilization Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process IRES-dependent Translational Initiation Cap-independent Translational Initiation Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Spermatogenesis Male Gamete Generation MRNA Destabilization Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Translation In Response To Stress Circadian Rhythm Macromolecule Biosynthetic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA
Tagcloud ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	aggressiveness blotting cadherin cck cyclind1 cyclind3 d3 downregulating expressions gastric ges hgc27 immortalized interfering invasion knockdown metallopeptidase mkn28 mta1 mucosal myc qrt silenced sirna suppressing transwell vimentin vimintin
Tagcloud (Difference) ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	aggressiveness blotting cadherin cck cyclind1 cyclind3 d3 downregulating expressions gastric ges hgc27 immortalized interfering knockdown metallopeptidase mkn28 mta1 mucosal myc qrt silenced sirna suppressing transwell vimentin vimintin
Tagcloud (Intersection) ?		invasion