KHSRP and EXOSC2

Number of citations of the paper that reports this interaction (PMID 15175153)
125

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		KHSRP	EXOSC2
Gene Name		KH-type splicing regulatory protein	exosome component 2
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cytoplasmic Stress Granule Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	DNA Binding MRNA Binding Poly(A) RNA Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Processing MRNA Catabolic Process RNA Splicing Gene Expression MRNA Transport Regulation Of MiRNA Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Gene Expression Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 PARN PTBP2 STK3	16 interactors: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MPP6 MRPL48 RNF8 SKIV2L2 ST6GALNAC1 UPF1 ZNF408
Entrez ID		8570	23404
HPRD ID		10350	03758
Ensembl ID		ENSG00000088247	ENSG00000130713
Uniprot IDs		Q92945	B3KQW2 Q13868
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	2NN6
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Processing Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Localization Nitrogen Compound Metabolic Process MRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process SnoRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance RRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process Maturation Of 5.8S RRNA Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process Gene Expression MRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process SnRNA Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death SnRNA Metabolic Process Regulation Of Growth Positive Regulation Of Cell Death MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Positive Regulation Of Protein Binding Negative Regulation Of Thymidylate Synthase Biosynthetic Process	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Aromatic Compound Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis DNA Deamination Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Maturation Of 5.8S RRNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process DNA Modification RRNA Catabolic Process Histone MRNA Metabolic Process Isotype Switching Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response DNA Metabolic Process Immunoglobulin Production Histone H2A K63-linked Ubiquitination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Positive Regulation Of Cell Growth MRNA Transport RNA Transport RNA Localization Leukocyte Activation Involved In Immune Response
Tagcloud ?		apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation
Tagcloud (Difference) ?		apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation
Tagcloud (Intersection) ?