PTBP2 and RBPMS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTBP2	RBPMS2
Description		polypyrimidine tract binding protein 2	RNA binding protein, mRNA processing factor 2
Image
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	MRNA Splice Site Recognition MRNA Processing RNA Splicing Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of BMP Signaling Pathway Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 20935630 28892062 28448500 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Daytime nap ( 33568662) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 22688191 19571811) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 30944420 32239398) Waist circumference ( 25673412)	Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Platelet count ( 32888494) PR interval ( 32439900)
Interacting Genes		26 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD ISY1 KHDRBS1 KHDRBS3 KHSRP LINC00624 MAGOH MATR3 OGT PCBP2 PCBP3 PRDX4 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA SRPK2 TOM1	68 interacting genes: ACTMAP AOC1 ARID5A BHLHE40 BOLL C10orf55 CAMK2A CBX2 CELF4 DND1 ESRP1 FAM168A FOXD4L1 FOXD4L3 FOXH1 FUBP3 HNRNPC HNRNPK HNRNPU IFIT2 KLF1 KLHDC7B KRTAP11-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LASP1 MAGED1 MKRN3 MSX2 MYPOP PATZ1 PCBP1 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PTBP2 RALY RBFOX1 RBFOX2 RBM3 RBM41 RBM42 RBM46 RBPMS RHOXF2 SEMA3B SNRPA SPMIP9 STRBP TENT5B TIAL1 UFSP1 UNC119 USP54 VHL VPS37C ZBTB32 ZC3H10 ZMAT5 ZNF34 ZNF385C
Entrez ID		58155	348093
HPRD ID		12233	18601
Ensembl ID		ENSG00000117569	ENSG00000166831
Uniprot IDs		A0A6Q8PFE6 A0A7I2RVZ4 B4DSS8 B4DSU5 Q9UKA9	Q6ZRY4
PDB IDs		2CQ1 2MJU 4CQ1	2M9K
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process MRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Splicing RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing RNA Processing RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MiRNA Binding Negative Regulation Of RNA Catabolic Process Nucleic Acid Metabolic Process Negative Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of Catabolic Process Ribonucleoprotein Complex Nucleus Positive Regulation Of Translation RNA Stabilization Regulation Of Translation Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Gene Expression Regulation Of Gene Expression Circadian Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR AU-rich Region Binding Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Nucleoplasm Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Metabolic Process Non-canonical Inflammasome Complex Assembly Negative Regulation Of Gene Expression	Nucleic Acid Binding Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Metabolic Process RNA Binding Regulation Of RNA Splicing MRNA Binding RNA Splicing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Stabilization MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Primary Metabolic Process Negative Regulation Of RNA Catabolic Process Intermediate Filament Negative Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Stability Regulation Of Macromolecule Biosynthetic Process MRNA 3'-UTR Binding Protein Binding Ribonucleoprotein Complex Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Pre-mRNA Binding Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression DNA Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II
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