KHSRP and EXOSC3

Number of citations of the paper that reports this interaction (PMID 15175153)
125

Data Source:
HPRD (in vitro, in vivo)

		KHSRP	EXOSC3
Gene Name		KH-type splicing regulatory protein	exosome component 3
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cytoplasmic Stress Granule Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	DNA Binding MRNA Binding Poly(A) RNA Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Processing MRNA Catabolic Process RNA Splicing Gene Expression MRNA Transport Regulation Of MiRNA Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Gene Expression Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 PARN PTBP2 STK3	8 interactors: APP ATP5D CDK5RAP1 EXOSC4 EXOSC5 EXOSC8 EXOSC9 KHSRP
Entrez ID		8570	51010
HPRD ID		10350	16220
Ensembl ID		ENSG00000088247	ENSG00000107371
Uniprot IDs		Q92945	Q9NQT5 Q9NYS3
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	2NN6
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Processing Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Localization Nitrogen Compound Metabolic Process MRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process SnoRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance RRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process Maturation Of 5.8S RRNA Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process Gene Expression MRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process SnRNA Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death SnRNA Metabolic Process Regulation Of Growth Positive Regulation Of Cell Death MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Positive Regulation Of Protein Binding Negative Regulation Of Thymidylate Synthase Biosynthetic Process	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process MRNA Metabolic Process RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Aromatic Compound Catabolic Process NcRNA Metabolic Process Ribosome Biogenesis Nuclear MRNA Surveillance Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Biogenesis DNA Deamination RNA Surveillance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Catabolic Process Cellular Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Gene Expression DNA Modification Synaptic Growth At Neuromuscular Junction Positive Regulation Of Cell Growth Regulation Of Growth Collateral Sprouting In Absence Of Injury Cellular Metabolic Process Defense Response To Virus Nuclear Polyadenylation-dependent RRNA Catabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Growth Neuron Remodeling Regulation Of MiRNA Metabolic Process Histone MRNA Catabolic Process Response To Virus Immune System Process RRNA Catabolic Process Regulation Of Cell Growth Mitochondrial ATP Synthesis Coupled Proton Transport Maturation Of 5.8S RRNA
Tagcloud ?		apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation	aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b spag5 synapt tryptic unsupervised urgent
Tagcloud (Difference) ?		apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation	aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b spag5 synapt tryptic unsupervised urgent
Tagcloud (Intersection) ?