KHSRP and NRON

Number of citations: 47 (PubMedID 37382239)
Data Source: BioGRID (unspecified method)

		KHSRP	NRON
Name		KH-type splicing regulatory protein	non-coding repressor of NFAT
Structure			No pdb structure
GO Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	None
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein Folding Chaperone	None
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Protein Folding RNA Splicing MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus	None
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	None
Drugs		Resveratrol Artenimol	None
GWAS		No GWAS studies recorded	Bipolar disorder ( 31043756 ) Eyebrow thickness ( 26926045 ) Malaria ( 31844061 )
Interacting Genes		17 interacting genes: A1CF APBB1 BACE1 CEBPA EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 MALAT1 NRON PARN PTBP2 SLC25A21-AS1 STK3 UBE2I	8 interacting genes: HNRNPU KHSRP MATR3 MDM2 MDM4 NFATC2 NUMB TP53
Entrez ID		8570	641373
HPRD ID		10350	Not available
Ensembl ID		ENSG00000088247	Not available
Uniprot IDs		M0R0C6 Q92945	Not available
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	Not available
GO Terms Enriched among Interactors		Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity CUT Catabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Metabolic Process TRNA Decay RNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Apoptotic Process SnRNA 3'-end Processing Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase Macromolecule Metabolic Process Nucleic Acid Binding MRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening SnRNA Processing Nuclear RNA Surveillance Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Surveillance Presynaptic Modulation Of Chemical Synaptic Transmission RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Microtubule Anchoring At Centrosome Spliceosomal Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Splicing PriRNA 3'-end Processing	Heart Valve Development Ventricular Septum Development Cellular Response To Actinomycin D Response To Actinomycin D Cardiac Septum Development DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To UV-C Transcription Repressor Complex Atrial Septum Development Cellular Response To Antibiotic Signal Transduction By P53 Class Mediator Response To UV-C Negative Regulation Of Transcription By RNA Polymerase II Nuclear Matrix Cellular Response To Hypoxia Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Response To Decreased Oxygen Levels Endocardial Cushion Morphogenesis Signal Transduction In Response To DNA Damage Atrioventricular Valve Morphogenesis Cellular Response To Oxygen Levels Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Disordered Domain Specific Binding Cellular Response To Gamma Radiation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process 14-3-3 Protein Binding Regulation Of ATP-dependent Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Negative Regulation Of Telomere Maintenance Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Ribonucleoprotein Complex Binding Negative Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Transcription By RNA Polymerase II Neuroblast Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Biological Quality Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Response To Xenobiotic Stimulus DNA Damage Response Response To Hypoxia Response To Gamma Radiation