KHSRP and GADD45A

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KHSRP	GADD45A
Description		KH-type splicing regulatory protein	growth arrest and DNA damage inducible alpha
Image
GO Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein Folding Chaperone	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Protein Folding RNA Splicing MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Apoptotic Process DNA Damage Response Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes
Drugs		Resveratrol Artenimol
Diseases
GWAS			Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		17 interacting genes: A1CF APBB1 BACE1 CEBPA EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 MALAT1 NRON PARN PTBP2 SLC25A21-AS1 STK3 UBE2I	69 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B CNOT9 DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4C16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PARVG PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135
Entrez ID		8570	1647
HPRD ID		10350	00528
Ensembl ID		ENSG00000088247	ENSG00000116717
Uniprot IDs		M0R0C6 Q92945	A5JUZ3 P24522
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	2KG4
Enriched GO Terms of Interacting Partners?		Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity CUT Catabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Metabolic Process TRNA Decay RNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Apoptotic Process SnRNA 3'-end Processing Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase Macromolecule Metabolic Process Nucleic Acid Binding MRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening SnRNA Processing Nuclear RNA Surveillance Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Surveillance Presynaptic Modulation Of Chemical Synaptic Transmission RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Microtubule Anchoring At Centrosome Spliceosomal Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Splicing PriRNA 3'-end Processing	Cellular Response To UV Response To UV Cellular Response To Light Stimulus Protein Kinase Binding Stress-induced Premature Senescence Molecular Function Activator Activity Nucleoplasm Positive Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Radiation Regulation Of Heart Growth Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Glucose Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Heart Growth Cyclin B1-CDK1 Complex PCNA-p21 Complex Nucleus Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Chromatin Organization Structural Constituent Of Chromatin Response To UV-C Regulation Of Growth Negative Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Extracellular Exosome Identical Protein Binding Cytosol Positive Regulation Of Organ Growth Regulation Of Developmental Growth Regulation Of Organ Growth Protein Localization To Organelle Centrosome Cycle Response To Light Stimulus Cellular Response To Actinomycin D Negative Regulation Of Biosynthetic Process Hexose Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Cellular Response To Nutrient Levels Protein Binding Nucleosome Assembly Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Actinomycin D
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