KHSRP and HNRNPH1

Number of citations of the paper that reports this interaction (PubMedID 11003644)
81

Data Source:
BioGRID (pull down, biochemical, affinity chromatography technology)

		KHSRP	HNRNPH1
Description		KH-type splicing regulatory protein	heterogeneous nuclear ribonucleoprotein H1
Image
GO Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein Folding Chaperone	Nucleic Acid Binding RNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Protein Folding RNA Splicing MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus	MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing Regulation Of RNA Splicing
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs		Resveratrol Artenimol	Copper
Diseases
GWAS			Daytime sleep phenotypes ( 27126917) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		17 interacting genes: A1CF APBB1 BACE1 CEBPA EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 MALAT1 NRON PARN PTBP2 SLC25A21-AS1 STK3 UBE2I	136 interacting genes: APBB1 ARHGEF16 CASP7 CATSPER1 CCDC120 CCNK CRMP1 DDX17 DUX4 DZIP3 ENKD1 ERG FOXP1 GPANK1 GPS2 HIPK3 HNRNPF HNRNPH3 HNRNPM KHSRP KRTAP13-2 LMO1 LMO3 LNX1 MAGED1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL53 MSI2 MTNR1A MYPOP NCBP1 NCBP2 NDRG1 NFKBID NUDT16L1 OGT OXER1 PATZ1 PCAT1 PEX5 PIN1 POLR1C RALY RAMAC RBFOX2 RBM38 RNF10 RNF4 SAXO4 SF1 SF3B4 SNRPB SNRPC SPG21 SREK1 SUMO2 SUMO4 TCERG1 TEKT3 TEKT4 TOM1L1 WEE2-AS1 YPEL3 YWHAG YWHAQ
Entrez ID		8570	3187
HPRD ID		10350	03021
Ensembl ID		ENSG00000088247	ENSG00000169045
Uniprot IDs		M0R0C6 Q92945	A0A384MEJ3 A0A9L9PY23 A0AAG2UWX3 E9PCY7 G8JLB6 H0YBD7 P31943
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	2LXU 6DHS 7ZUG
Enriched GO Terms of Interacting Partners?		Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity CUT Catabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Metabolic Process TRNA Decay RNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Apoptotic Process SnRNA 3'-end Processing Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase Macromolecule Metabolic Process Nucleic Acid Binding MRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening SnRNA Processing Nuclear RNA Surveillance Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Surveillance Presynaptic Modulation Of Chemical Synaptic Transmission RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Microtubule Anchoring At Centrosome Spliceosomal Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Splicing PriRNA 3'-end Processing	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Locomotion Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of MRNA Stability Negative Regulation Of Cytokine Production Regulation Of RNA Stability Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility
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