PTBP2 and RBM4

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		PTBP2	RBM4
Gene Name		polypyrimidine tract binding protein 2	RNA binding motif protein 4
Image
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytoplasmic Stress Granule Nuclear Speck
	Molecular Function	Nucleotide Binding MRNA Binding Poly(A) RNA Binding	Nucleotide Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding MiRNA Binding Poly(A) RNA Binding Pre-mRNA Intronic Binding Pre-mRNA Intronic Pyrimidine-rich Binding
	Biological Process	MRNA Splice Site Selection Negative Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	Regulation Of Alternative MRNA Splicing, Via Spliceosome Cap-independent Translational Initiation IRES-dependent Translational Initiation RNA Processing MRNA Processing RNA Splicing Negative Regulation Of Translation Cell Differentiation Negative Regulation Of Translation In Response To Stress Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Translational Initiation Response To Arsenic-containing Substance Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Circadian Regulation Of Translation
Pathways
Drugs
Diseases
GWAS		Body mass index ( 20935630) Schizophrenia ( 19571811 22688191)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		17 interactors: CALCOCO2 EIF5A2 ELAVL1 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 SNRPA TOM1	29 interactors: AQR CCNA1 CDK2 CXorf56 DDX17 DDX5 DGCR14 DHX9 HNRNPF HNRNPH2 HNRNPH3 HNRNPK HNRNPM HNRNPUL1 LRP2BP PABPC1 PRPF31 PTBP2 RBM10 RBM22 RBM23 RBM42 RBM7 SF1 SF3B4 SMAD5 SNRPC TRIB3 U2AF2
Entrez ID		58155	5936
HPRD ID		12233	03982
Ensembl ID		ENSG00000117569	ENSG00000173933
Uniprot IDs		Q9UKA9	Q9BWF3
PDB IDs		2CQ1	2DNQ
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Gene Expression Positive Regulation Of Translation RNA Metabolic Process Circadian Regulation Of Translation RNA Splicing, Via Transesterification Reactions 3'-UTR-mediated MRNA Stabilization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process MRNA Transport RNA Transport RNA Localization Nitrogen Compound Metabolic Process MRNA Stabilization Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Polyamine Homeostasis Regulation Of Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of RNA Export From Nucleus 3'-UTR-mediated MRNA Destabilization Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process IRES-dependent Translational Initiation Cap-independent Translational Initiation Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Spermatogenesis Male Gamete Generation MRNA Destabilization Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Translation In Response To Stress Circadian Rhythm Macromolecule Biosynthetic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Processing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing Regulation Of Nitrogen Compound Metabolic Process MRNA Splice Site Selection Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Ribonucleoprotein Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway MRNA Cis Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Ribonucleoprotein Complex Biogenesis MRNA Stabilization Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Spliceosomal SnRNP Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Meiotic Cell Cycle Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression
Tagcloud ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	ago2 altogether argonaute2 associates c2c12 cap colocalizes cytoplasm deposited entry granules micro micrornas microtubule mrnas myoblast notably participates potentiates recruit ribonucleoprotein ribonucleoproteins ribosome rnas suppress suppresses transiently translation translocates
Tagcloud (Difference) ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	ago2 altogether argonaute2 associates c2c12 cap colocalizes cytoplasm deposited entry granules micro micrornas microtubule mrnas myoblast notably participates potentiates recruit ribonucleoprotein ribonucleoproteins ribosome rnas suppress suppresses transiently translation translocates
Tagcloud (Intersection) ?