PTBP2 and TOM1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PTBP2	TOM1
Gene Name		polypyrimidine tract binding protein 2	target of myb1 (chicken)
Image
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex	Cytoplasm Endosome Early Endosome Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding MRNA Binding Poly(A) RNA Binding	Protein Binding Clathrin Binding
	Biological Process	MRNA Splice Site Selection Negative Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	Intracellular Protein Transport Endocytosis Protein Transport Endosomal Transport
Pathways
Drugs
Diseases
GWAS		Body mass index ( 20935630) Schizophrenia ( 19571811 22688191)
Protein-Protein Interactions		17 interactors: CALCOCO2 EIF5A2 ELAVL1 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 SNRPA TOM1	14 interactors: APP CLTC EEA1 ILVBL MYO6 NEDD4 PTBP2 RPS27 SSBP2 TOLLIP UBC UBE2D1 ZFYVE16 ZNF512B
Entrez ID		58155	10043
HPRD ID		12233	05265
Ensembl ID		ENSG00000117569	ENSG00000100284
Uniprot IDs		Q9UKA9	B3KUF5 O60784
PDB IDs		2CQ1	1ELK 1WRD
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Gene Expression Positive Regulation Of Translation RNA Metabolic Process Circadian Regulation Of Translation RNA Splicing, Via Transesterification Reactions 3'-UTR-mediated MRNA Stabilization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process MRNA Transport RNA Transport RNA Localization Nitrogen Compound Metabolic Process MRNA Stabilization Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Polyamine Homeostasis Regulation Of Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of RNA Export From Nucleus 3'-UTR-mediated MRNA Destabilization Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process IRES-dependent Translational Initiation Cap-independent Translational Initiation Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Spermatogenesis Male Gamete Generation MRNA Destabilization Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Translation In Response To Stress Circadian Rhythm Macromolecule Biosynthetic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA	Intracellular Transport Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Establishment Of Localization In Cell Protein Targeting To Lysosome Endocytosis Protein Localization To Lysosome Regulation Of Nitrogen Compound Metabolic Process Cellular Protein Localization Protein Targeting To Vacuole Protein Targeting Membrane Organization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Establishment Of Protein Localization To Vacuole Intracellular Protein Transport Protein Polyubiquitination Synapse Organization Protein Localization To Organelle Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Endosomal Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus Receptor Internalization Regulation Of Cell Cycle Phase Transition Lysosomal Transport Regulation Of Transcription From RNA Polymerase II Promoter Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Protein Localization Neuromuscular Junction Development Regulation Of Gene Expression Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cytoplasmic Transport Immune Response Positive Regulation Of Proteolysis Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Synaptic Vesicle To Endosome Fusion Transmission Of Virus Development Involved In Symbiotic Interaction TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 myo6 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 ubbd ubbddelta weakened
Tagcloud (Difference) ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 myo6 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 ubbd ubbddelta weakened
Tagcloud (Intersection) ?