KHSRP and TNFSF9

Data Source: HiPPIP (Novel)

		KHSRP	TNFSF9
Name		KH-type splicing regulatory protein	TNF superfamily member 9
Structure
GO Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Extracellular Space Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein Folding Chaperone	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Protein Folding RNA Splicing MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus	Immune Response Cell Communication Signal Transduction Cell-cell Signaling Signaling Positive Regulation Of Activated T Cell Proliferation Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Cytotoxic T Cell Differentiation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	TNFs bind their physiological receptors
Drugs		Resveratrol Artenimol	None
GWAS		No GWAS studies recorded	Metabolite levels ( 23823483 )
Interacting Genes		17 interacting genes: A1CF APBB1 BACE1 CEBPA EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 MALAT1 NRON PARN PTBP2 SLC25A21-AS1 STK3 UBE2I	3 interacting genes: TNFRSF9 TRAF1 TRAF2
Entrez ID		8570	8744
HPRD ID		10350	05861
Ensembl ID		ENSG00000088247	ENSG00000125657
Uniprot IDs		M0R0C6 Q92945	A0A0U5J8I0 P41273
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	2X29 6A3V 6BWV 6CPR 6CU0 6D3N 6FIB 6MGE 6MGP
GO Terms Enriched among Interactors		Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity CUT Catabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Metabolic Process TRNA Decay RNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Apoptotic Process SnRNA 3'-end Processing Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase Macromolecule Metabolic Process Nucleic Acid Binding MRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening SnRNA Processing Nuclear RNA Surveillance Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Surveillance Presynaptic Modulation Of Chemical Synaptic Transmission RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Microtubule Anchoring At Centrosome Spliceosomal Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Splicing PriRNA 3'-end Processing	Thioesterase Binding Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity TORC2 Complex Disassembly Positive Regulation Of DNA-binding Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Endopeptidase Clp Complex Cell Death Programmed Cell Death Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Sphingolipid Binding Regulation Of MRNA Stability Regulation Of RNA Stability IRE1-TRAF2-ASK1 Complex CD27 Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding ATP-dependent Peptidase Activity Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding CD40 Receptor Complex Regulation Of MRNA Metabolic Process CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of JUN Kinase Activity Interleukin-17-mediated Signaling Pathway Mitochondrial Protein Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Apoptotic Signaling Pathway TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Cellular Response To Reactive Nitrogen Species Negative Regulation Of Nitric Oxide Biosynthetic Process Exosome (RNase Complex) Negative Regulation Of Lipoprotein Particle Clearance 3'-UTR-mediated MRNA Destabilization Cytokine-mediated Signaling Pathway Regulation Of Low-density Lipoprotein Particle Clearance Response To Nitric Oxide Programmed Necrotic Cell Death