PTBP2 and GBP1

		PTBP2	GBP1
Description		polypyrimidine tract binding protein 2	guanylate binding protein 1
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GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body	Golgi Membrane Extracellular Region Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Symbiont Cell Surface
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Nucleotide Binding Lipopolysaccharide Binding Actin Binding GTPase Activity G Protein Activity GDP Phosphatase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Enzyme Binding Cytokine Binding Spectrin Binding Identical Protein Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	MRNA Splice Site Recognition MRNA Processing RNA Splicing Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	Immune System Process Negative Regulation Of Interleukin-2 Production Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Protein Maturation Defense Response To Virus Cytolysis In Another Organism Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Protein Localization To Vacuole Positive Regulation Of Pyroptotic Inflammatory Response Non-canonical Inflammasome Complex Assembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Plasma Membrane
Pathways			Interferon gamma signaling CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 20935630 28892062 28448500 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Daytime nap ( 33568662) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 22688191 19571811) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 30944420 32239398) Waist circumference ( 25673412)	Remission after SSRI treatment in MDD or openness ( 29559929) Serum metabolite levels ( 33031748)
Interacting Genes		26 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD ISY1 KHDRBS1 KHDRBS3 KHSRP LINC00624 MAGOH MATR3 OGT PCBP2 PCBP3 PRDX4 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA SRPK2 TOM1	2 interacting genes: FNTA FNTB
Entrez ID		58155	2633
HPRD ID		12233	02681
Ensembl ID		ENSG00000117569	ENSG00000117228
Uniprot IDs		A0A6Q8PFE6 A0A7I2RVZ4 B4DSS8 B4DSU5 Q9UKA9	P32455
PDB IDs		2CQ1 2MJU 4CQ1	1DG3 1F5N 2B8W 2B92 2BC9 2D4H 6K1Z 6K2D 6LOJ 8CQB 8Q4L 8R1A
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process MRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Splicing RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing RNA Processing RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MiRNA Binding Negative Regulation Of RNA Catabolic Process Nucleic Acid Metabolic Process Negative Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of Catabolic Process Ribonucleoprotein Complex Nucleus Positive Regulation Of Translation RNA Stabilization Regulation Of Translation Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Gene Expression Regulation Of Gene Expression Circadian Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR AU-rich Region Binding Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Nucleoplasm Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Metabolic Process Non-canonical Inflammasome Complex Assembly Negative Regulation Of Gene Expression	Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Protein Prenyltransferase Activity Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Microtubule Associated Complex Regulation Of Microtubule-based Movement Peptide Pheromone Maturation CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Regulation Of Microtubule-based Process Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Protein Geranylgeranylation Enzyme Binding Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Nuclear Envelope Organization Negative Regulation Of RNA Splicing Peptide Binding Spinal Cord Development Regulation Of Rac Protein Signal Transduction MRNA Splice Site Recognition Neuromuscular Junction Development Alpha-tubulin Binding Receptor Clustering Cerebellum Development Receptor Tyrosine Kinase Binding Positive Regulation Of Small GTPase Mediated Signal Transduction
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