PTBP2 and RBM10

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTBP2	RBM10
Gene Name		polypyrimidine tract binding protein 2	RNA binding motif protein 10
Image
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding MRNA Binding Poly(A) RNA Binding	Nucleotide Binding Protein Binding Zinc Ion Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Splice Site Selection Negative Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	MRNA Processing Biological_process RNA Splicing
Pathways
Drugs
Diseases
GWAS		Body mass index ( 20935630) Schizophrenia ( 19571811 22688191)
Protein-Protein Interactions		17 interactors: CALCOCO2 EIF5A2 ELAVL1 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 SNRPA TOM1	21 interactors: AES ATN1 CCAR1 CSNK2A1 DDX5 FAM124A HNRNPH2 HNRNPK IK NHP2L1 PRCC PTBP1 PTBP2 RBM4 SF1 SF3A1 SREK1 SRSF6 TBC1D22B U2AF1 UBQLN4
Entrez ID		58155	8241
HPRD ID		12233	02095
Ensembl ID		ENSG00000117569	ENSG00000182872
Uniprot IDs		Q9UKA9	P98175 Q7Z3D7
PDB IDs		2CQ1	2LXI 2M2B
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Gene Expression Positive Regulation Of Translation RNA Metabolic Process Circadian Regulation Of Translation RNA Splicing, Via Transesterification Reactions 3'-UTR-mediated MRNA Stabilization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process MRNA Transport RNA Transport RNA Localization Nitrogen Compound Metabolic Process MRNA Stabilization Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Polyamine Homeostasis Regulation Of Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of RNA Export From Nucleus 3'-UTR-mediated MRNA Destabilization Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process IRES-dependent Translational Initiation Cap-independent Translational Initiation Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Spermatogenesis Male Gamete Generation MRNA Destabilization Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Translation In Response To Stress Circadian Rhythm Macromolecule Biosynthetic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing RNA Metabolic Process Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Splice Site Selection Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of MRNA Processing Ribonucleoprotein Complex Biogenesis MRNA 3'-splice Site Recognition Ribonucleoprotein Complex Assembly Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Termination Of RNA Polymerase II Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process MRNA Export From Nucleus Cellular Macromolecular Complex Assembly DNA-templated Transcription, Termination Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Export From Nucleus Regulation Of Metabolic Process MRNA 3'-end Processing Biosynthetic Process Primary Sex Determination Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Anoikis RNA 3'-end Processing Negative Regulation Of Biosynthetic Process IRES-dependent Translational Initiation
Tagcloud ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	abcc12 braf dabrafenib deregulated deserve detoxification discover exploratory highlighted invasiveness klf17 melanoma mtefd1 nqo1 peaks responder responders rin1 seldi silico slain1 strongest surrogates tox3 tspo2 v600 vemurafenib z zbtb44
Tagcloud (Difference) ?		17beta abolishment adenocarcinoma asos colony downregulated downregulation dramatically e2 ectopic emt eralpha estradiol estrogen evaluating invasion malat mesenchymal migration mir necessity os osteoblast osteosarcoma posttranscriptionally remarkably sfpq transcript ways	abcc12 braf dabrafenib deregulated deserve detoxification discover exploratory highlighted invasiveness klf17 melanoma mtefd1 nqo1 peaks responder responders rin1 seldi silico slain1 strongest surrogates tox3 tspo2 v600 vemurafenib z zbtb44
Tagcloud (Intersection) ?