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DGKZ and RB1
Number of citations of the paper that reports this interaction (PMID
16286473
)
9
Data Source:
HPRD
(in vivo, in vitro)
DGKZ
RB1
Gene Name
diacylglycerol kinase, zeta
retinoblastoma 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Plasma Membrane
Lamellipodium
Chromatin
Nucleus
Nucleoplasm
Spindle
SWI/SNF Complex
PML Body
Rb-E2F Complex
Molecular Function
Lipid Kinase Activity
NAD+ Kinase Activity
Diacylglycerol Kinase Activity
Enzyme Inhibitor Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Metal Ion Binding
Core Promoter Binding
RNA Polymerase II Activating Transcription Factor Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Androgen Receptor Binding
Phosphoprotein Binding
Biological Process
Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway
Blood Coagulation
Phosphorylation
Cell Migration
Platelet Activation
Mitotic G1 DNA Damage Checkpoint
Intracellular Signal Transduction
Negative Regulation Of Catalytic Activity
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Ras Protein Signal Transduction
Lipid Phosphorylation
Cell Cycle Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Chromatin Remodeling
Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Cell Cycle Arrest
Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis
Mitotic Cell Cycle Checkpoint
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Viral Process
Androgen Receptor Signaling Pathway
Sister Chromatid Biorientation
Neuron Projection Development
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Striated Muscle Cell Differentiation
Cell Division
Neuron Apoptotic Process
Protein Localization To Chromosome, Centromeric Region
Regulation Of Cohesin Localization To Chromatin
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
G alpha (q) signalling events
G alpha (q) signalling events
Signaling by GPCR
GPCR downstream signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Platelet activation, signaling and aggregation
Effects of PIP2 hydrolysis
E2F mediated regulation of DNA replication
DNA Damage/Telomere Stress Induced Senescence
Synthesis of DNA
Mitotic Prophase
Cellular Senescence
G1 Phase
Regulation of DNA replication
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Orc1 removal from chromatin
S Phase
Cyclin E associated events during G1/S transition
Cell Cycle, Mitotic
M Phase
Orc1 removal from chromatin
Cyclin D associated events in G1
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
G1/S Transition
Removal of licensing factors from origins
Cyclin A:Cdk2-associated events at S phase entry
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Condensation of Prophase Chromosomes
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS
Immunoglobulin A (
20694011
)
Protein-Protein Interactions
18 interactors:
DMD
HRAS
LEPR
MAPK6
PLCG1
POLR2M
PRKCA
RASGRP1
RB1
RBL1
RBL2
SAT1
SNTA1
SNTB1
SNTB2
SNTG1
SNX27
SRC
167 interactors:
AATF
ABL1
AHR
AR
ARID3B
ATF2
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX1
CBX4
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CREG1
CTBP1
CUX1
DGKZ
DNMT1
DNMT3A
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FOS
FRK
GNB2L1
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
L3MBTL1
LIN54
LIN9
LMNA
MAPK1
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCOA6
NDC80
NEFM
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RAF1
RBAK
RBBP4
RBBP5
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF40
RUNX2
SERPINB2
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
SUMO1
SUMO2
SUV39H1
SUV420H2
TAF1
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TRAP1
TRIM27
TRIP11
UBE2I
UBTF
UHRF2
USP4
USP7
VDR
ZBTB16
Entrez ID
8525
5925
HPRD ID
03260
01574
Ensembl ID
ENSG00000149091
ENSG00000139687
Uniprot IDs
B7Z6M3
F6UCU9
Q13574
P06400
PDB IDs
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4ELJ
4ELL
Enriched GO Terms of Interacting Partners
?
Regulation Of Lipid Kinase Activity
Regulation Of Kinase Activity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Phosphorylation
Negative Regulation Of Peptidyl-cysteine S-nitrosylation
Regulation Of Phosphorus Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cell Communication
Cellular Response To Fibroblast Growth Factor Stimulus
Blood Coagulation
Response To Fibroblast Growth Factor
Hemostasis
Regulation Of Catalytic Activity
Neurotrophin TRK Receptor Signaling Pathway
Ras Protein Signal Transduction
Neurotrophin Signaling Pathway
Intracellular Signal Transduction
Leukocyte Migration
Cell Cycle
Regulation Of Cell Cycle
Positive Regulation Of Macrophage Differentiation
Fc Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Cellular Response To Growth Factor Stimulus
Wound Healing
Response To Growth Factor
Regulation Of Lipid Metabolic Process
Regulation Of Cellular Localization
Signaling
Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Cellular Component Movement
Regulation Of Cellular Component Movement
Response To Wounding
Positive Regulation Of Locomotion
Positive Regulation Of ERK1 And ERK2 Cascade
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Protein Kinase Activity
Mitotic Cell Cycle
Regulation Of Epithelial Cell Migration
Negative Regulation Of Catalytic Activity
Regulation Of Muscle Contraction
Organelle Localization
Signal Transduction
Regulation Of Immune System Process
Innate Immune Response
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Cell Cycle
RNA Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Cellular Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Mitotic Cell Cycle
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Modification
Cellular Response To Stress
Cell Cycle Process
Chromatin Organization
Mitotic Cell Cycle Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chromosome Organization
Cellular Response To DNA Damage Stimulus
Regulation Of Cellular Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Tagcloud
?
13q14
16q22
18q21
1p35
22p
22q
3p22
5q21
8p
9p21
apc
cent
crc
crcs
dcc
dukes
existed
frequencies
heterozygosity
loh
microsatellite
pairwise
q14
q22
rer
sporadic
ucacrc
ucacrcs
ulcerative
Tagcloud (Difference)
?
13q14
16q22
18q21
1p35
22p
22q
3p22
5q21
8p
9p21
apc
cent
crc
crcs
dcc
dukes
existed
frequencies
heterozygosity
loh
microsatellite
pairwise
q14
q22
rer
sporadic
ucacrc
ucacrcs
ulcerative
Tagcloud (Intersection)
?