DGKZ and RBL2

Number of citations of the paper that reports this interaction (PubMedID 16286473)
0

Data Source:
HPRD (in vitro, in vivo)

		DGKZ	RBL2
Description		diacylglycerol kinase zeta	RB transcriptional corepressor like 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Lamellipodium Cell Projection Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Lipid Kinase Activity ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Alkylglycerol Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell Migration Platelet Activation Mitotic G1 DNA Damage Checkpoint Signaling Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Effects of PIP2 hydrolysis	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes
Drugs		alpha-Tocopherol succinate
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Body size at age 10 ( 32376654) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 28991256 29483656)	Appendicular lean mass ( 33097823) Body fat mass ( 28552196) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: DMD HRAS LEPR MAPK6 PLCG1 POLR2M PRKCA RASGRP1 RB1 RBL1 RBL2 SAT1 SNTA1 SNTB1 SNTB2 SNTG1 SNX27 SRC TP53	46 interacting genes: BRCA1 BRF1 BRF2 BTG3 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB1 PPP1R9B PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1
Entrez ID		8525	5934
HPRD ID		03260	01576
Ensembl ID		ENSG00000149091	ENSG00000103479
Uniprot IDs		Q13574	Q08999
PDB IDs		5ELQ	4XI9 5C1D
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Syntrophin Complex Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Intracellular Signaling Cassette Ras Protein Signal Transduction Regulation Of Tissue Remodeling Glial Cell Proliferation Regulation Of Kinase Activity Protein-containing Complex Glial Cell Apoptotic Process Regulation Of Bone Remodeling Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Structural Molecule Activity Actin Binding Regulation Of Cell Cycle G1/S Phase Transition Intracellular Signal Transduction Promoter-specific Chromatin Binding Nitric-oxide Synthase Binding Negative Regulation Of Mitotic Cell Cycle Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Phase Transition Diacylglycerol Binding Transcription Regulator Complex Positive Regulation Of Macrophage Differentiation Negative Regulation Of Glial Cell Proliferation Small GTPase-mediated Signal Transduction Ruffle Membrane Regulation Of Mitotic Cell Cycle Regulation Of Heart Rate Negative Regulation Of Cell Cycle Process Regulation Of ERK1 And ERK2 Cascade Neuron Apoptotic Process Sarcolemma Regulation Of Macrophage Differentiation Positive Regulation Of Developmental Process Disordered Domain Specific Binding Cellular Response To Gamma Radiation Regulation Of Multicellular Organismal Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Developmental Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Immune System Process Cytoskeleton	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Nucleus Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cyclin A2-CDK2 Complex Cell Division Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Response To Stress Transcription Regulator Complex DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Transcription Preinitiation Complex Assembly
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