DGKZ and RBL1

Number of citations of the paper that reports this interaction (PMID 16286473)
9

Data Source:
HPRD (in vitro, in vivo)

		DGKZ	RBL1
Gene Name		diacylglycerol kinase, zeta	retinoblastoma-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Lamellipodium	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Lipid Kinase Activity NAD+ Kinase Activity Diacylglycerol Kinase Activity Enzyme Inhibitor Activity Protein Binding ATP Binding Protein C-terminus Binding Metal Ion Binding	Protein Binding Transcription Factor Binding
	Biological Process	Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Phosphorylation Cell Migration Platelet Activation Mitotic G1 DNA Damage Checkpoint Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Lipid Phosphorylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Chromatin Modification Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)
Protein-Protein Interactions		18 interactors: DMD HRAS LEPR MAPK6 PLCG1 POLR2M PRKCA RASGRP1 RB1 RBL1 RBL2 SAT1 SNTA1 SNTB1 SNTB2 SNTG1 SNX27 SRC	51 interactors: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 SUV420H2 TAF1 TOP1 USP4
Entrez ID		8525	5933
HPRD ID		03260	00312
Ensembl ID		ENSG00000149091	ENSG00000080839
Uniprot IDs		B7Z6M3 F6UCU9 Q13574	P28749
PDB IDs			1H28
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Blood Coagulation Response To Fibroblast Growth Factor Hemostasis Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Intracellular Signal Transduction Leukocyte Migration Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Macrophage Differentiation Fc Receptor Signaling Pathway Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Regulation Of Lipid Metabolic Process Regulation Of Cellular Localization Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cellular Component Movement Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Locomotion Positive Regulation Of ERK1 And ERK2 Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Epithelial Cell Migration Negative Regulation Of Catalytic Activity Regulation Of Muscle Contraction Organelle Localization Signal Transduction Regulation Of Immune System Process Innate Immune Response	Transcription From RNA Polymerase II Promoter Cell Cycle Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Cell Cycle Process Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Multicellular Organismal Development
Tagcloud ?			accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide
Tagcloud (Difference) ?			accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide
Tagcloud (Intersection) ?