DGKZ and LEPR

Number of citations of the paper that reports this interaction (PubMedID 11078732)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		DGKZ	LEPR
Description		diacylglycerol kinase zeta	leptin receptor
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Lamellipodium Cell Projection Glutamatergic Synapse	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Lipid Kinase Activity ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Alkylglycerol Kinase Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity Signaling Receptor Activity Identical Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell Migration Platelet Activation Mitotic G1 DNA Damage Checkpoint Signaling Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway	Angiogenesis Glycogen Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Glial Cell Proliferation Cytokine-mediated Signaling Pathway Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling System Development Regulation Of Transport Regulation Of Feeding Behavior Energy Homeostasis Cell Surface Receptor Signaling Pathway Via STAT Bone Growth Positive Regulation Of Cold-induced Thermogenesis Transport Across Blood-brain Barrier
Pathways		Effects of PIP2 hydrolysis
Drugs		alpha-Tocopherol succinate	Leptin Metreleptin
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Body size at age 10 ( 32376654) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 28991256 29483656)	Adult body size ( 32376654) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Blood protein levels ( 30072576) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 3 months old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI at adiposity peak ( 31840077) Body size at age 10 ( 32376654) C-reactive protein ( 23844046 18439548 22939635 19567438) C-reactive protein levels ( 33339817 21300955 29878111 30388399) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Eosinophil percentage of white cells ( 32888494) Fasting plasma glucose (childhood) ( 25223902) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Hip circumference ( 28552196) Iron status biomarkers (iron levels) ( 33536631) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Metabolic traits ( 19060910) Molybdenum levels ( 26025379) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Nonalcoholic steatohepatitis ( 32298765) Obesity (early onset extreme) ( 23563609) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33547301) Soluble leptin receptor levels ( 20167575) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		19 interacting genes: DMD HRAS LEPR MAPK6 PLCG1 POLR2M PRKCA RASGRP1 RB1 RBL1 RBL2 SAT1 SNTA1 SNTB1 SNTB2 SNTG1 SNX27 SRC TP53	17 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 USP7 XRN1
Entrez ID		8525	3953
HPRD ID		03260	03001
Ensembl ID		ENSG00000149091	ENSG00000116678
Uniprot IDs		Q13574	P48357 Q4G138
PDB IDs		5ELQ	3V6O 6E2P 7Z3Q 8AVE 8AVF 8AVO 8X80 8X81 8X85
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Syntrophin Complex Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Intracellular Signaling Cassette Ras Protein Signal Transduction Regulation Of Tissue Remodeling Glial Cell Proliferation Regulation Of Kinase Activity Protein-containing Complex Glial Cell Apoptotic Process Regulation Of Bone Remodeling Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Structural Molecule Activity Actin Binding Regulation Of Cell Cycle G1/S Phase Transition Intracellular Signal Transduction Promoter-specific Chromatin Binding Nitric-oxide Synthase Binding Negative Regulation Of Mitotic Cell Cycle Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Phase Transition Diacylglycerol Binding Transcription Regulator Complex Positive Regulation Of Macrophage Differentiation Negative Regulation Of Glial Cell Proliferation Small GTPase-mediated Signal Transduction Ruffle Membrane Regulation Of Mitotic Cell Cycle Regulation Of Heart Rate Negative Regulation Of Cell Cycle Process Regulation Of ERK1 And ERK2 Cascade Neuron Apoptotic Process Sarcolemma Regulation Of Macrophage Differentiation Positive Regulation Of Developmental Process Disordered Domain Specific Binding Cellular Response To Gamma Radiation Regulation Of Multicellular Organismal Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Developmental Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Immune System Process Cytoskeleton	Leptin Receptor Binding Retromer, Tubulation Complex Insulin Receptor Binding Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Peptide Hormone Receptor Binding Transferrin Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Metabolic Process Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Autophagy Retromer Complex Negative Regulation Of Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Cytosol Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Autophagy Phosphatidylinositol Binding Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Regulation Of Hormone Secretion Regulation Of Intracellular Transport Epidermal Growth Factor Receptor Binding Regulation Of Nucleocytoplasmic Transport Regulation Of Transport Regulation Of Immune System Process Regulation Of Defense Response Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hormone Secretion Establishment Of Protein Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus
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