DGKZ and SNX27

Number of citations of the paper that reports this interaction (PubMedID 17351151)
0

Data Source:
HPRD (two hybrid, in vivo)

		DGKZ	SNX27
Description		diacylglycerol kinase zeta	sorting nexin 27
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Lamellipodium Cell Projection Glutamatergic Synapse	Immunological Synapse Cytoplasm Endosome Early Endosome Cytosol Membrane Retromer Complex Early Endosome Membrane WASH Complex Schaffer Collateral - CA1 Synapse Postsynapse Postsynaptic Recycling Endosome Postsynaptic Early Endosome Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Lipid Kinase Activity ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Alkylglycerol Kinase Activity	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell Migration Platelet Activation Mitotic G1 DNA Damage Checkpoint Signaling Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Protein Transport Endosomal Transport Endocytic Recycling Regulation Of Synapse Maturation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Effects of PIP2 hydrolysis
Drugs		alpha-Tocopherol succinate
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Body size at age 10 ( 32376654) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 28991256 29483656)	Body mass index ( 26426971)
Interacting Genes		19 interacting genes: DMD HRAS LEPR MAPK6 PLCG1 POLR2M PRKCA RASGRP1 RB1 RBL1 RBL2 SAT1 SNTA1 SNTB1 SNTB2 SNTG1 SNX27 SRC TP53	16 interacting genes: ACE2 ACVR2B APP BRSK2 CDK16 DGKZ ERBB4 HLCS PDGFRB PNPLA3 PTEN RPS6KA1 SELP SUMO2 UBC VANGL2
Entrez ID		8525	81609
HPRD ID		03260	11591
Ensembl ID		ENSG00000149091	ENSG00000143376
Uniprot IDs		Q13574	A0A2R8Y8A7 Q96L92
PDB IDs		5ELQ	4HAS 5ZN9 6SAK 7CT1 7E0B 7P72 7PCB 8TTT 8TTU 8TTV
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Syntrophin Complex Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Intracellular Signaling Cassette Ras Protein Signal Transduction Regulation Of Tissue Remodeling Glial Cell Proliferation Regulation Of Kinase Activity Protein-containing Complex Glial Cell Apoptotic Process Regulation Of Bone Remodeling Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Structural Molecule Activity Actin Binding Regulation Of Cell Cycle G1/S Phase Transition Intracellular Signal Transduction Promoter-specific Chromatin Binding Nitric-oxide Synthase Binding Negative Regulation Of Mitotic Cell Cycle Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Phase Transition Diacylglycerol Binding Transcription Regulator Complex Positive Regulation Of Macrophage Differentiation Negative Regulation Of Glial Cell Proliferation Small GTPase-mediated Signal Transduction Ruffle Membrane Regulation Of Mitotic Cell Cycle Regulation Of Heart Rate Negative Regulation Of Cell Cycle Process Regulation Of ERK1 And ERK2 Cascade Neuron Apoptotic Process Sarcolemma Regulation Of Macrophage Differentiation Positive Regulation Of Developmental Process Disordered Domain Specific Binding Cellular Response To Gamma Radiation Regulation Of Multicellular Organismal Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Developmental Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Immune System Process Cytoskeleton	Kinase Activity Protein Metabolic Process Phosphorylation Regulation Of Cell Communication Protein Kinase Activity Regulation Of Signaling Protein Modification Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Migration Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Synaptic Vesicle Clustering ATP Binding Cell Motility Receptor Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleotide Binding Transferase Activity Regulation Of Signal Transduction Retina Vasculature Development In Camera-type Eye Protein Tag Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Macromolecule Metabolic Process Response To Growth Factor Anatomical Structure Morphogenesis Establishment Of Planar Polarity System Development Regulation Of Reactive Oxygen Species Metabolic Process Phosphatidic Acid Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Apical Plasma Membrane Regulation Of Smooth Muscle Cell Proliferation Axonogenesis Protein Serine/threonine Kinase Activity Enzyme Binding Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Phosphatidic Acid Metabolic Process Plasma Membrane Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion
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