DGKZ and RASGRP1

Number of citations of the paper that reports this interaction (PubMedID 11257115)
38

Data Source:
HPRD (in vitro, in vivo)

		DGKZ	RASGRP1
Description		diacylglycerol kinase zeta	RAS guanyl releasing protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Lamellipodium Cell Projection Glutamatergic Synapse	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Lipid Kinase Activity ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Alkylglycerol Kinase Activity	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Phosphatidylcholine Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell Migration Platelet Activation Mitotic G1 DNA Damage Checkpoint Signaling Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway	Positive Regulation Of Protein Phosphorylation Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune System Process Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Natural Killer Cell Activation Cell Differentiation Secretory Granule Localization Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus T Cell Proliferation B Cell Proliferation T Cell Activation B Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Leukocyte Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Regulation Of Intracellular Signal Transduction
Pathways		Effects of PIP2 hydrolysis	Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade
Drugs		alpha-Tocopherol succinate
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Body size at age 10 ( 32376654) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 28991256 29483656)	Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 18711365) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Crohn's disease ( 23128233 28067908) Estimated glomerular filtration rate ( 30604766) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Mild age-related type 2 diabetes ( 34737425) Multiple sclerosis ( 24076602) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Psychosis (atypical) ( 24132900) Rheumatoid arthritis ( 32723749 24390342 30423114 23143596 30572963) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 33272962 28714469) Type 1 diabetes ( 25751624 21829393 18840781) Type 2 diabetes ( 30718926 30297969 32499647 28254843 22961080)
Interacting Genes		19 interacting genes: DMD HRAS LEPR MAPK6 PLCG1 POLR2M PRKCA RASGRP1 RB1 RBL1 RBL2 SAT1 SNTA1 SNTB1 SNTB2 SNTG1 SNX27 SRC TP53	2 interacting genes: DGKZ HRAS
Entrez ID		8525	10125
HPRD ID		03260	04909
Ensembl ID		ENSG00000149091	ENSG00000172575
Uniprot IDs		Q13574	B2RA89 O95267
PDB IDs		5ELQ	4L9M 4L9U
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Syntrophin Complex Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Intracellular Signaling Cassette Ras Protein Signal Transduction Regulation Of Tissue Remodeling Glial Cell Proliferation Regulation Of Kinase Activity Protein-containing Complex Glial Cell Apoptotic Process Regulation Of Bone Remodeling Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Structural Molecule Activity Actin Binding Regulation Of Cell Cycle G1/S Phase Transition Intracellular Signal Transduction Promoter-specific Chromatin Binding Nitric-oxide Synthase Binding Negative Regulation Of Mitotic Cell Cycle Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Phase Transition Diacylglycerol Binding Transcription Regulator Complex Positive Regulation Of Macrophage Differentiation Negative Regulation Of Glial Cell Proliferation Small GTPase-mediated Signal Transduction Ruffle Membrane Regulation Of Mitotic Cell Cycle Regulation Of Heart Rate Negative Regulation Of Cell Cycle Process Regulation Of ERK1 And ERK2 Cascade Neuron Apoptotic Process Sarcolemma Regulation Of Macrophage Differentiation Positive Regulation Of Developmental Process Disordered Domain Specific Binding Cellular Response To Gamma Radiation Regulation Of Multicellular Organismal Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Developmental Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Immune System Process Cytoskeleton
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?