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REPS1 and CRK
Number of citations of the paper that reports this interaction (PMID
9395447
)
25
Data Source:
HPRD
(in vitro)
REPS1
CRK
Gene Name
RALBP1 associated Eps domain containing 1
v-crk avian sarcoma virus CT10 oncogene homolog
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Coated Pit
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Extracellular Vesicular Exosome
Molecular Function
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
SH3/SH2 Adaptor Activity
Protein Binding
SH2 Domain Binding
Protein Phosphorylated Amino Acid Binding
Ephrin Receptor Binding
Biological Process
Receptor-mediated Endocytosis
Activation Of MAPKK Activity
Regulation Of Transcription From RNA Polymerase II Promoter
Blood Coagulation
Insulin Receptor Signaling Pathway
Platelet Activation
Regulation Of Rho GTPase Activity
Regulation Of Actin Cytoskeleton Organization
Regulation Of Rac Protein Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Pathways
Signalling to ERKs
Prolonged ERK activation events
Platelet Aggregation (Plug Formation)
VEGFA-VEGFR2 Pathway
Regulation of signaling by CBL
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Signaling by Insulin receptor
Innate Immune System
Signaling by PDGF
Signalling by NGF
Insulin receptor signalling cascade
p130Cas linkage to MAPK signaling for integrins
Integrin alphaIIb beta3 signaling
Cytokine Signaling in Immune system
NGF signalling via TRKA from the plasma membrane
ARMS-mediated activation
Signaling by Interleukins
Signal attenuation
Signaling by VEGF
Downstream signal transduction
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
13 interactors:
ATF4
CRK
GRB2
HSF1
ITSN2
PIN1
RAB11FIP2
RALA
RALB
RALBP1
REPS2
TRAPPC2L
WWC2
84 interactors:
ABL1
ABL2
ARHGAP17
ARHGAP32
ASAP1
ATXN1
AVIL
BCAR1
BCR
BUB1
CBL
CBLC
CRKL
DAB1
DOCK1
DOCK3
DOK1
DOK4
DPPA4
EFS
EGFR
EPHA3
EPHB2
EPHB3
EPHB6
EPS15
ERBB2
ERBB3
ERBB4
FAM154A
FASLG
FGFR1
FLT1
FRS2
FYN
GAB1
GRB2
IGF1R
INSR
IRS1
IRS2
IRS4
KDR
KHDRBS1
KIT
MAP4K1
MAP4K5
MAPK4
MAPK8
MICAL1
NCK1
NEDD9
NTRK1
PDGFRA
PDGFRB
PIK3R1
PLSCR1
POT1
PPFIBP2
PPP1CA
PSMC6
PTK2
PTK2B
PTPN1
PTPN4
PXN
RAPGEF1
REPS1
RET
SH3BP1
SHB
SHC1
SOCS1
SOS1
SPRR2A
STAT5A
STAT5B
SYN1
TERF2IP
VAV1
WASF1
WEE1
XPO1
ZAP70
Entrez ID
85021
1398
HPRD ID
09687
01267
Ensembl ID
ENSG00000135597
ENSG00000167193
Uniprot IDs
J3KP76
Q96D71
L7RT18
P46108
PDB IDs
1JU5
2DVJ
2EYV
2EYW
2EYX
2EYY
2EYZ
Enriched GO Terms of Interacting Partners
?
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Rho GTPase Activity
Response To Organic Substance
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Rho Protein Signal Transduction
Vesicle-mediated Transport
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Catalytic Activity
Positive Regulation Of Metabolic Process
Regulation Of Ras GTPase Activity
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Transferase Activity
Ras Protein Signal Transduction
Cellular Response To Growth Factor Stimulus
Response To External Stimulus
Response To Growth Factor
Small GTPase Mediated Signal Transduction
Positive Regulation Of Rho GTPase Activity
Cellular Response To Stimulus
Regulation Of Ras Protein Signal Transduction
Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Regulation Of Small GTPase Mediated Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Exocyst Assembly
Signaling
Regulation Of GTPase Activity
Cell Communication
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Phosphorylation
Regulation Of Exocyst Localization
Positive Regulation Of Autophagic Vacuole Assembly
Positive Regulation Of Vacuole Organization
Positive Regulation Of Protein Modification Process
Regulation Of Organelle Organization
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Ras GTPase Activity
Cytokinesis
Positive Regulation Of Hydrolase Activity
Embryonic Placenta Development
Positive Regulation Of Protein Kinase Activity
Regulation Of Signal Transduction
Regulation Of Protein Phosphorylation
Response To Stimulus
Positive Regulation Of Kinase Activity
Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signaling
ERBB Signaling Pathway
Regulation Of Signal Transduction
Signaling
Positive Regulation Of Signal Transduction
Signal Transduction
Cell Communication
Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Intracellular Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Intracellular Signal Transduction
Regulation Of Catalytic Activity
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Stimulus
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Organic Substance
Positive Regulation Of Catalytic Activity
Protein Autophosphorylation
Fc Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Stimulus
Cellular Response To Organonitrogen Compound
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Phosphorylation
Response To Organic Substance
Phosphatidylinositol-mediated Signaling
Regulation Of Immune Response
Protein Phosphorylation
Cellular Response To Fibroblast Growth Factor Stimulus
Peptidyl-amino Acid Modification
Immune Response-regulating Signaling Pathway
Response To Fibroblast Growth Factor
Positive Regulation Of Metabolic Process
Regulation Of Phosphorus Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of MAPK Cascade
Immune System Process
Positive Regulation Of Transferase Activity
Phosphorylation
Cellular Response To Peptide
Positive Regulation Of MAPK Cascade
Fc-epsilon Receptor Signaling Pathway
Innate Immune Response
Tagcloud
?
abundantly
adhesions
arises
associating
carboxy
cas
conferring
connect
coordinating
dim1p
efs
encompassed
encompasses
fyn
hef1
identifies
interactor
localize
multidomain
oncoproteins
p105
p115
p130
p55
sh3
sin
spindle
sum
unexpectedly
Tagcloud (Difference)
?
abundantly
adhesions
arises
associating
carboxy
cas
conferring
connect
coordinating
dim1p
efs
encompassed
encompasses
fyn
hef1
identifies
interactor
localize
multidomain
oncoproteins
p105
p115
p130
p55
sh3
sin
spindle
sum
unexpectedly
Tagcloud (Intersection)
?