REPS1 and REPS2

Number of citations: 0 (PubMedID 9422736)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		REPS1	REPS2
Name		RALBP1 associated Eps domain containing 1	RALBP1 associated Eps domain containing 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Endocytosis Endosomal Transport	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Protein-containing Complex Assembly
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
GWAS		Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 ) Type 2 diabetes ( 32499647 )	No GWAS studies recorded
Interacting Genes		19 interacting genes: AKT1 ANKRD1 ATF4 CRK FLNC GRB2 HSF1 ITSN1 ITSN2 MZT1 PIN1 RAB11FIP2 RALA RALB RALBP1 REPS2 TRAPPC2 TRAPPC2L WWC2	15 interacting genes: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 ITCH ITSN1 PXN RALB RALBP1 RELA REPS1
Entrez ID		85021	9185
HPRD ID		09687	02262
Ensembl ID		ENSG00000135597	ENSG00000169891
Uniprot IDs		B2R7D3 Q96D71	Q8NFH8
PDB IDs		Not available	1IQ3
GO Terms Enriched among Interactors		Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Intracellular Signaling Cassette Import Into Cell Intracellular Signal Transduction Clathrin-dependent Synaptic Vesicle Endocytosis Cytosol Protein-macromolecule Adaptor Activity Small GTPase-mediated Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Signal Transduction Organelle Organization Cellular Response To Decreased Oxygen Levels Response To Decreased Oxygen Levels Regulation Of Organelle Organization Cellular Response To Oxygen Levels Response To Oxygen Levels Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling PERK-mediated Unfolded Protein Response Receptor Internalization Establishment Of Protein Localization To Mitochondrion General Transcription Initiation Factor Binding TRAPPII Protein Complex TRAPPIII Protein Complex ERBB Signaling Pathway Ras Protein Signal Transduction Regulation Of Innate Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Kinase Binding Cellular Localization Positive Regulation Of Protein Localization To Membrane Regulation Of Intracellular Signal Transduction TRAPP Complex Cytoplasm Positive Regulation Of Growth Positive Regulation Of Organelle Assembly Kinase Binding Positive Regulation Of Cellular Component Biogenesis Intracellular Vesicle Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Organization Response To Hypoxia	Endocytosis Receptor-mediated Endocytosis Import Into Cell Positive Regulation Of Cellular Component Organization Receptor Internalization Clathrin-coated Pit Cytosol Vesicle-mediated Transport Positive Regulation Of Organelle Organization Regulation Of Schwann Cell Differentiation Regulation Of Cellular Component Organization Plasma Membrane Postsynaptic Endocytic Zone Protein-macromolecule Adaptor Activity Cytoplasm Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Signaling Cellular Response To Reactive Oxygen Species SH3 Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway RNA Polymerase II Core Promoter Sequence-specific DNA Binding Symbiont Entry Into Host Cell Response To Oxidative Stress Regulation Of Signal Transduction Response To Reactive Oxygen Species Biological Process Involved In Interaction With Host Regulation Of Organelle Organization Endosome Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Cytoskeleton Organization Prostate Induction Positive Regulation Of Metabolic Process Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Male Somatic Sex Determination Pronuclear Fusion Cellular Response To Oxidative Stress Centrosome Cycle Positive Regulation Of Cellular Component Biogenesis Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Exocyst Assembly Doxorubicin Transport Transcription Coactivator Binding