REPS1 and TRAPPC2L

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		REPS1	TRAPPC2L
Name		RALBP1 associated Eps domain containing 1	trafficking protein particle complex subunit 2L
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPII Protein Complex TRAPPIII Protein Complex
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Protein Binding
	Biological Process	Endocytosis Endosomal Transport	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport COPII Vesicle Coating Vesicle Tethering
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
GWAS		Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 ) Type 2 diabetes ( 32499647 )	Carotid intima media thickness (mean) ( 31801372 ) Hair color ( 26926045 )
Interacting Genes		19 interacting genes: AKT1 ANKRD1 ATF4 CRK FLNC GRB2 HSF1 ITSN1 ITSN2 MZT1 PIN1 RAB11FIP2 RALA RALB RALBP1 REPS2 TRAPPC2 TRAPPC2L WWC2	26 interacting genes: APP BLZF1 BSDC1 C11orf68 CEP57L1 GPANK1 LCN2 LHX2 LMO3 MEI4 MEOX1 MEOX2 POLR2G RABEP1 REL REPS1 SSX2 SSX2B TCF4 TRAPPC3 TRAPPC3L TRAPPC6A TRIP6 UBC YPEL3 ZBTB42
Entrez ID		85021	51693
HPRD ID		09687	13711
Ensembl ID		ENSG00000135597	ENSG00000167515
Uniprot IDs		B2R7D3 Q96D71	A0A0B4J294 H3BQQ8 H3BUK6 Q9UL33
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Intracellular Signaling Cassette Import Into Cell Intracellular Signal Transduction Clathrin-dependent Synaptic Vesicle Endocytosis Cytosol Protein-macromolecule Adaptor Activity Small GTPase-mediated Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Signal Transduction Organelle Organization Cellular Response To Decreased Oxygen Levels Response To Decreased Oxygen Levels Regulation Of Organelle Organization Cellular Response To Oxygen Levels Response To Oxygen Levels Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling PERK-mediated Unfolded Protein Response Receptor Internalization Establishment Of Protein Localization To Mitochondrion General Transcription Initiation Factor Binding TRAPPII Protein Complex TRAPPIII Protein Complex ERBB Signaling Pathway Ras Protein Signal Transduction Regulation Of Innate Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Kinase Binding Cellular Localization Positive Regulation Of Protein Localization To Membrane Regulation Of Intracellular Signal Transduction TRAPP Complex Cytoplasm Positive Regulation Of Growth Positive Regulation Of Organelle Assembly Kinase Binding Positive Regulation Of Cellular Component Biogenesis Intracellular Vesicle Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Organization Response To Hypoxia	TRAPP Complex Somite Specification Golgi Vesicle Transport Cis-Golgi Network Membrane TRAPPIII Protein Complex Segment Specification Somite Development