REPS1 and RALB

Number of citations: 0 (PubMedID 9422736)
Data Source: HPRD (in vitro)

		REPS1	RALB
Name		RALBP1 associated Eps domain containing 1	RAS like proto-oncogene B
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane	Plasma Membrane Membrane Midbody Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Ubiquitin Protein Ligase Binding ATPase Binding
	Biological Process	Endocytosis Endosomal Transport	Regulation Of Exocyst Assembly Apoptotic Process Signal Transduction Ras Protein Signal Transduction Receptor Internalization Positive Regulation Of Innate Immune Response Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Division Regulation Of Exocyst Localization Positive Regulation Of Autophagosome Assembly
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	p38MAPK events
GWAS		Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 ) Type 2 diabetes ( 32499647 )	Breast size ( 27182965 ) Intraocular pressure ( 29617998 ) Mean platelet volume ( 27863252 32888494 ) Metabolite levels ( 23823483 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 )
Interacting Genes		19 interacting genes: AKT1 ANKRD1 ATF4 CRK FLNC GRB2 HSF1 ITSN1 ITSN2 MZT1 PIN1 RAB11FIP2 RALA RALB RALBP1 REPS2 TRAPPC2 TRAPPC2L WWC2	7 interacting genes: CALM1 INCA1 PLCD1 RALBP1 REPS1 REPS2 RGL4
Entrez ID		85021	5899
HPRD ID		09687	01550
Ensembl ID		ENSG00000135597	ENSG00000144118
Uniprot IDs		B2R7D3 Q96D71	P11234
PDB IDs		Not available	2KE5 2KWI 6ZQT 6ZRN
GO Terms Enriched among Interactors		Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Intracellular Signaling Cassette Import Into Cell Intracellular Signal Transduction Clathrin-dependent Synaptic Vesicle Endocytosis Cytosol Protein-macromolecule Adaptor Activity Small GTPase-mediated Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Signal Transduction Organelle Organization Cellular Response To Decreased Oxygen Levels Response To Decreased Oxygen Levels Regulation Of Organelle Organization Cellular Response To Oxygen Levels Response To Oxygen Levels Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling PERK-mediated Unfolded Protein Response Receptor Internalization Establishment Of Protein Localization To Mitochondrion General Transcription Initiation Factor Binding TRAPPII Protein Complex TRAPPIII Protein Complex ERBB Signaling Pathway Ras Protein Signal Transduction Regulation Of Innate Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Kinase Binding Cellular Localization Positive Regulation Of Protein Localization To Membrane Regulation Of Intracellular Signal Transduction TRAPP Complex Cytoplasm Positive Regulation Of Growth Positive Regulation Of Organelle Assembly Kinase Binding Positive Regulation Of Cellular Component Biogenesis Intracellular Vesicle Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Organization Response To Hypoxia	Endocytosis Intracellular Signaling Cassette Import Into Cell Calcium Ion Binding Signal Transduction Intracellular Signal Transduction Plasma Membrane C-X-C Motif Chemokine 12 Receptor Activity Doxorubicin Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Vesicle-mediated Transport Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-mediated Signaling Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Autophagosome Membrane Docking Spindle Pole Phosphatidylinositol Phospholipase C Activity Anion Binding Phospholipase C/protein Kinase C Signal Transduction CXCL12-activated CXCR4 Signaling Pathway Myosin Light Chain Binding Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway C-X-C Chemokine Receptor CXCR4 Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity ABC-type Glutathione S-conjugate Transporter Activity Protein-macromolecule Adaptor Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity