REPS1 and ATF4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		REPS1	ATF4
Gene Name		RALBP1 associated Eps domain containing 1	activating transcription factor 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Coated Pit	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Dendrite Membrane Nuclear Periphery Neuron Projection Lewy Body Core ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Receptor-mediated Endocytosis	Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Amino Acid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways			ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		13 interactors: ATF4 CRK GRB2 HSF1 ITSN2 PIN1 RAB11FIP2 RALA RALB RALBP1 REPS2 TRAPPC2L WWC2	65 interactors: APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CKAP4 CREB3 CREBZF DAPK3 DDIT3 DISC1 EGLN3 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA POLR2C PTCD3 REPS1 RPS6 SNAP29 SRA1 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226
Entrez ID		85021	468
HPRD ID		09687	06817
Ensembl ID		ENSG00000135597	ENSG00000128272
Uniprot IDs		J3KP76 Q96D71	P18848 Q96AQ3
PDB IDs			1CI6
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Rho GTPase Activity Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Regulation Of Rho Protein Signal Transduction Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Ras GTPase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Ras Protein Signal Transduction Cellular Response To Growth Factor Stimulus Response To External Stimulus Response To Growth Factor Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Cellular Response To Stimulus Regulation Of Ras Protein Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Small GTPase Mediated Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Exocyst Assembly Signaling Regulation Of GTPase Activity Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Regulation Of Exocyst Localization Positive Regulation Of Autophagic Vacuole Assembly Positive Regulation Of Vacuole Organization Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Ras GTPase Activity Cytokinesis Positive Regulation Of Hydrolase Activity Embryonic Placenta Development Positive Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of Kinase Activity Intracellular Signal Transduction	Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Myeloid Cell Differentiation Leukocyte Differentiation Cellular Metabolic Process Response To Stress Apoptotic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Organ Development Myeloid Leukocyte Differentiation Defense Response Programmed Cell Death Immune System Process Response To Stimulus Cell Death Death Hemopoiesis Response To External Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?			activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?			activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?