SENP3 and SUMO2

Number of citations of the paper that reports this interaction (PMID 11029585)
45

Data Source:
HPRD (two hybrid, in vitro)

		SENP3	SUMO2
Gene Name		SUMO1/sentrin/SMT3 specific peptidase 3	small ubiquitin-like modifier 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm MLL1 Complex	Nucleus Nucleoplasm PML Body
	Molecular Function	Protein Binding Cysteine-type Peptidase Activity	Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding
	Biological Process	Proteolysis	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS		IgM levels ( 23118916)
Protein-Protein Interactions		13 interactors: ATF7IP CDK4 CDK6 EP300 HIC1 MDM2 NPM1 PARP1 SUMO2 TRIM54 TRIM63 USP15 USP21	91 interactors: ALAS1 ARL13A ARNTL ATXN1 ATXN7 AURKB BAD BCL11A BLM BRCC3 BRE C18orf25 CCNE2 CDCA8 CENPC CHAF1A CHD3 CMTM6 CORO2A CSNK2B CUL3 FAM175A FOS HDAC4 HDAC9 HIF1A HIPK2 HNF4A HOMEZ HSF2 JUN KALRN KDM1A KRT14 KRT5 KRT8 LEF1 MAF1 MAST2 MDC1 MSX1 MYB NFKBIA PARP1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAC1 RANGAP1 RB1 RNF111 RNF4 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SH3KBP1 SLC22A2 SNCA SOX10 SOX6 SP100 STK24 SUMO1 TDG TDP2 TEAD3 TNIP1 TOPORS TP53BP2 TRIM63 UBA2 UBE2I USP25 USPL1 VIM WRN XPC ZBTB1 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM5
Entrez ID		26168	6613
HPRD ID		08339	04332
Ensembl ID		ENSG00000161956	ENSG00000188612
Uniprot IDs		Q9H4L4	P61956
PDB IDs			1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2RPQ 3UIN 3UIO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Chromosome Organization Chromatin Organization Regulation Of Gene Expression Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Protein Catabolic Process Histone Deubiquitination Negative Regulation Of Cell Cycle Arrest Cellular Response To DNA Damage Stimulus Regulation Of Protein Metabolic Process Response To Organic Cyclic Compound Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Signaling Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Regulation Of Cell Cycle Cell Communication Response To Steroid Hormone Response To Hormone Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Cellular Process Response To Organic Substance Cell Cycle Process Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Negative Regulation Of Transcription, DNA-templated Cellular Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Cellular Response To Organic Substance Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Cellular Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Peptidyl-lysine Modification Proteasomal Protein Catabolic Process	Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding RNA Metabolic Process Cellular Metabolic Process Gene Expression Chromosome Organization Organelle Organization Regulation Of DNA Binding Biosynthetic Process Response To Stimulus Regulation Of Cellular Process Cellular Response To Stimulus Negative Regulation Of Binding Protein Modification By Small Protein Conjugation Peptidyl-amino Acid Modification Regulation Of Cell Differentiation Regulation Of Signal Transduction Cellular Response To Stress
Tagcloud ?		adaptive allowing cathepsin conjugation cytochrome degraded deprivation desumoylation determinants drp1 extreme facilitates fate fission gtpase ischaemia modifier ogd perk prolongs protects recover reoxygenation rnai sumo sumoylation suppresses unfolded upr	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Difference) ?		adaptive allowing cathepsin conjugation cytochrome degraded deprivation desumoylation determinants drp1 extreme fission gtpase ischaemia modifier ogd perk prolongs protects recover reoxygenation rnai sumo sumoylation suppresses unfolded upr	augment consequent delaying elusive emerged enhance enhancing fasting linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Intersection) ?		facilitates fate