SENP3 and NPM1

Number of citations of the paper that reports this interaction (PMID 18259216)
32

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SENP3	NPM1
Gene Name		SUMO1/sentrin/SMT3 specific peptidase 3	nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm MLL1 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome
	Molecular Function	Protein Binding Cysteine-type Peptidase Activity	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding
	Biological Process	Proteolysis	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Pathways			Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins
Drugs
Diseases
GWAS		IgM levels ( 23118916)
Protein-Protein Interactions		13 interactors: ATF7IP CDK4 CDK6 EP300 HIC1 MDM2 NPM1 PARP1 SUMO2 TRIM54 TRIM63 USP15 USP21	53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1
Entrez ID		26168	4869
HPRD ID		08339	01246
Ensembl ID		ENSG00000161956	ENSG00000181163
Uniprot IDs		Q9H4L4	P06748
PDB IDs			2LLH 2P1B 2VXD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Chromosome Organization Chromatin Organization Regulation Of Gene Expression Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Protein Catabolic Process Histone Deubiquitination Negative Regulation Of Cell Cycle Arrest Cellular Response To DNA Damage Stimulus Regulation Of Protein Metabolic Process Response To Organic Cyclic Compound Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Signaling Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Regulation Of Cell Cycle Cell Communication Response To Steroid Hormone Response To Hormone Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Cellular Process Response To Organic Substance Cell Cycle Process Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Negative Regulation Of Transcription, DNA-templated Cellular Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Cellular Response To Organic Substance Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Cellular Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Peptidyl-lysine Modification Proteasomal Protein Catabolic Process	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		adaptive allowing cathepsin conjugation cytochrome degraded deprivation desumoylation determinants drp1 extreme facilitates fate fission gtpase ischaemia modifier ogd perk prolongs protects recover reoxygenation rnai sumo sumoylation suppresses unfolded upr	aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Difference) ?		adaptive allowing cathepsin conjugation cytochrome degraded deprivation desumoylation determinants drp1 extreme facilitates fate fission gtpase ischaemia modifier ogd perk prolongs protects recover reoxygenation rnai sumo sumoylation suppresses unfolded upr	aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Intersection) ?