SENP3 and CDCA8

Number of citations of the paper that reports this interaction (PubMedID 18946085)
57

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		SENP3	CDCA8
Description		SUMO specific peptidase 3	cell division cycle associated 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Body MLL1 Complex	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity	Protein Binding
	Biological Process	Proteolysis Protein Desumoylation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cytokinesis Mitotic Metaphase Chromosome Alignment Mitotic Spindle Midzone Assembly Chromosome Organization Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Refractive error ( 32231278) Serum metabolite levels ( 33031748)	Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		20 interacting genes: ADRB2 ATF7IP BECN1 CDCA8 CDK4 CDK6 CEP19 DNM1L EP300 HIC1 MED25 MTHFD1 NPM1 PARP1 PELP1 SUMO2 TRIM54 TRIM63 USP15 USP21	28 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GAS2L3 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP KMT2E MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277
Entrez ID		26168	55143
HPRD ID		08339	13017
Ensembl ID		ENSG00000161956	ENSG00000134690
Uniprot IDs		Q9H4L4	Q53HL2
PDB IDs			2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH 7U5V 8RUP 8RUQ
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Transcription Regulator Complex Nucleoplasm Regulation Of Signal Transduction By P53 Class Mediator Regulation Of RNA Metabolic Process Protein-DNA Complex Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Organelle Organization Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Remodeling Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Metaphase Plate Congression Cellular Response To UV Regulation Of Fibroblast Proliferation Regulation Of Muscle System Process Protein-containing Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Light Stimulus Chromatin Organization Regulation Of Cellular Response To Stress Negative Regulation Of Small Molecule Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle G2/M Phase Transition Ubiquitin Protein Ligase Binding Negative Regulation Of ATP Metabolic Process Regulation Of Phosphorus Metabolic Process Mononuclear Cell Differentiation Regulation Of Gene Expression Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Small Molecule Metabolic Process	Chromosome Segregation Chromosome Passenger Complex Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Nuclear Body Repair Of Mitotic Kinetochore Microtubule Attachment Defect Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Cell Cycle Checkpoint SUMO Transferase Activity Chromosome, Centromeric Region Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Chromosome Separation Chromosome Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Chromosome Segregation SUMO Ligase Complex Mitotic Spindle Organization Positive Regulation Of Chromosome Separation Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Cytokinesis Mitotic Spindle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation Mitotic Cell Cycle Regulation Of Nuclear Division Protein Sumoylation Nucleoplasm Spindle Organization Mitotic Cytokinesis Chromocenter Regulation Of Mitotic Cell Cycle Phase Transition SUMO Ligase Activity Protein Localization To Kinetochore Meiotic Chromosome Segregation Nucleus Regulation Of Cytokinesis Condensed Chromosome, Centromeric Region
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?