FOXN1 and CDC23

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOXN1	CDC23
Description		forkhead box N1	cell division cycle 23
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Hair Follicle Development Lymphocyte Homeostasis T Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Epidermis Development Animal Organ Morphogenesis Regulation Of Gene Expression Hemopoiesis Cell Differentiation Keratinocyte Differentiation Positive Regulation Of Epithelial Cell Differentiation Regulation Of T Cell Differentiation In Thymus Nail Development T Cell Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Thymus Development Positive Regulation Of Hair Follicle Development Lymphoid Lineage Cell Migration Into Thymus Thymus Epithelium Morphogenesis Regulation Of Positive Thymic T Cell Selection	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Chromosome Alignment Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Bone mineral density ( 31790847) Metabolite levels ( 31628463) Tonsillectomy ( 27182965 28928442)	Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)
Interacting Genes		13 interacting genes: CDA CDC23 DMRT3 HOXA1 LHX8 MAPKBP1 OTUD3 PIN1 SPATC1L TLE5 TRAF2 TRAPPC6A TSSK1B	78 interacting genes: ANAPC10 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FOXN1 GORASP2 GPRASP3 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1
Entrez ID		8456	8697
HPRD ID		02907	07221
Ensembl ID		ENSG00000109101	ENSG00000094880
Uniprot IDs		O15353	Q9UJX2
PDB IDs		5OCN 6EL8	4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?