FOXN1 and LHX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOXN1	LHX8
Description		forkhead box N1	LIM homeobox 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Hair Follicle Development Lymphocyte Homeostasis T Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Epidermis Development Animal Organ Morphogenesis Regulation Of Gene Expression Hemopoiesis Cell Differentiation Keratinocyte Differentiation Positive Regulation Of Epithelial Cell Differentiation Regulation Of T Cell Differentiation In Thymus Nail Development T Cell Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Thymus Development Positive Regulation Of Hair Follicle Development Lymphoid Lineage Cell Migration Into Thymus Thymus Epithelium Morphogenesis Regulation Of Positive Thymic T Cell Selection	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Forebrain Neuron Development Neuron Differentiation Response To Ethanol
Pathways
Drugs
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Bone mineral density ( 31790847) Metabolite levels ( 31628463) Tonsillectomy ( 27182965 28928442)
Interacting Genes		13 interacting genes: CDA CDC23 DMRT3 HOXA1 LHX8 MAPKBP1 OTUD3 PIN1 SPATC1L TLE5 TRAF2 TRAPPC6A TSSK1B	26 interacting genes: - ABI2 ATF2 ATF6B AXIN1 BANP CCHCR1 CRK CSNK2A1 EFS FIGLA FOSL2 FOXN1 GINS4 KLF3 KRT85 LDB2 NEDD9 NUTM1 PLCG2 PRPF31 SCYL3 SUV39H1 TBC1D1 TBC1D22B ZBTB24
Entrez ID		8456	431707
HPRD ID		02907	17275
Ensembl ID		ENSG00000109101	ENSG00000162624
Uniprot IDs		O15353	Q68G74
PDB IDs		5OCN 6EL8
Enriched GO Terms of Interacting Partners?			NK T Cell Differentiation Nucleus Protein Tyrosine Kinase Binding Response To Endothelin Cellular Response To Endothelin RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cell Development Signaling Adaptor Activity Response To Yeast Epigenetic Programming In The Zygotic Pronuclei DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II
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