FOXN1 and TSSK1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOXN1	TSSK1B
Description		forkhead box N1	testis specific serine kinase 1B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Acrosomal Vesicle Cytoplasm Cilium Cytoplasmic Vesicle Motile Cilium Cell Projection
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Hair Follicle Development Lymphocyte Homeostasis T Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Epidermis Development Animal Organ Morphogenesis Regulation Of Gene Expression Hemopoiesis Cell Differentiation Keratinocyte Differentiation Positive Regulation Of Epithelial Cell Differentiation Regulation Of T Cell Differentiation In Thymus Nail Development T Cell Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Thymus Development Positive Regulation Of Hair Follicle Development Lymphoid Lineage Cell Migration Into Thymus Thymus Epithelium Morphogenesis Regulation Of Positive Thymic T Cell Selection	Protein Phosphorylation Spermatogenesis Spermatid Development Cell Differentiation
Pathways
Drugs			Fostamatinib
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Bone mineral density ( 31790847) Metabolite levels ( 31628463) Tonsillectomy ( 27182965 28928442)
Interacting Genes		13 interacting genes: CDA CDC23 DMRT3 HOXA1 LHX8 MAPKBP1 OTUD3 PIN1 SPATC1L TLE5 TRAF2 TRAPPC6A TSSK1B	8 interacting genes: CHEK2 EFS FAM229B FOXN1 MEOX2 TGFBR1 TGFBR2 TSKS
Entrez ID		8456	83942
HPRD ID		02907	11610
Ensembl ID		ENSG00000109101	ENSG00000212122
Uniprot IDs		O15353	A0ZT98 Q9BXA7
PDB IDs		5OCN 6EL8
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Ligand-receptor Complex Roof Of Mouth Development Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Blood Vessel Morphogenesis Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Binding Response To Cholesterol Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Tissue Development Lens Development In Camera-type Eye Thymus Development SMAD Binding Tube Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of SMAD Protein Signal Transduction Artery Morphogenesis Cell Proliferation Involved In Endocardial Cushion Morphogenesis Positive Regulation Of Tolerance Induction To Self Antigen Superior Endocardial Cushion Morphogenesis Inferior Endocardial Cushion Morphogenesis Cardiac Septum Morphogenesis Embryonic Skeletal System Morphogenesis Epithelial To Mesenchymal Transition Tissue Morphogenesis Regulation Of Stem Cell Proliferation Protein Serine/threonine Kinase Activity Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Hematopoietic Or Lymphoid Organ Development Bronchus Morphogenesis Transforming Growth Factor Beta Receptor Activity, Type II Positive Regulation Of B Cell Tolerance Induction Mammary Gland Morphogenesis Lymphoid Lineage Cell Migration Into Thymus Thymus Epithelium Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Proepicardium Development
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