LCOR and RAP1GAP

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	RAP1GAP
Description		ligand dependent nuclear receptor corepressor	RAP1 GTPase activating protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Golgi Membrane Cytoplasm Early Endosome Golgi Apparatus Cytosol Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Adaptive Immune Response Phagocytosis Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Cell-cell Adhesion Negative Regulation Of Microvillus Assembly Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor
Pathways			Rap1 signalling RET signaling
Drugs
Diseases
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	18 interacting genes: AFDN BRAF CDK1 CSNK1G2 DSCR9 DYNC1I1 GNAZ LCOR MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A VPS26C ZBTB12
Entrez ID		84458	5909
HPRD ID		07609	02609
Ensembl ID		ENSG00000196233	ENSG00000076864
Uniprot IDs		Q96JN0	P47736 X6R8W7
PDB IDs		2COB 6V3X 6V3Y	1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Protein Phosphorylation Phosphorylation Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Negative Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Exocytosis Kinase Activity Phosphate-containing Compound Metabolic Process Mitotic Nuclear Membrane Disassembly Regulation Of Neurotransmitter Secretion Nuclear Membrane Disassembly Membrane Disassembly Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Protein Localization Protein Localization To Site Of Double-strand Break Regulation Of Secretion Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Secretion By Cell Postsynaptic Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Positive Regulation Of Protein Modification Process Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Exocytosis Establishment Of Endothelial Barrier Chromosome Condensation Negative Regulation Of Secretion Positive Regulation Of D-glucose Transmembrane Transport Pronuclear Fusion Spindle Microtubule Endothelial Cell Development Peptidyl-serine Phosphorylation Regulation Of Exocytosis Protein Modification Process Nuclear Membrane Organization Centrosome Cycle Sperm Midpiece Presynapse Intracellular Signal Transduction Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Phosphorylation Modulation Of Chemical Synaptic Transmission MAPK Cascade ERK1 And ERK2 Cascade Positive Regulation Of Stress Fiber Assembly
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