RAP1GAP and DYNC1I1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RAP1GAP	DYNC1I1
Gene Name		RAP1 GTPase activating protein	dynein, cytoplasmic 1, intermediate chain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Membrane	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Ras GTPase Binding Protein Homodimerization Activity Rap GTPase Activator Activity	Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding
	Biological Process	Signal Transduction Metabolic Process Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity Negative Regulation Of Microvillus Assembly	Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule
Pathways		Rap1 signalling Adaptive Immune System	MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS		Liver enzyme levels ( 18940312)	Immune reponse to smallpox (secreted IL-10) ( 22610502) Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B MLLT4 PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12	31 interactors: ANXA7 BICD1 C2orf44 CADM4 CDKN1A DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 MCC NAGK NUDT21 PIN1 RAP1GAP RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 UBC
Entrez ID		5909	1780
HPRD ID		02609	04798
Ensembl ID		ENSG00000076864	ENSG00000158560
Uniprot IDs		P47736	A4D1I7 B4DME3 F5H050 G5E9K1 O14576 Q8N542 Q8TBF7
PDB IDs		1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Catalytic Activity Mitotic Nuclear Envelope Disassembly Regulation Of Synaptic Vesicle Transport Nuclear Envelope Disassembly Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Neurotransmitter Secretion Activation Of MAPKK Activity Nuclear Envelope Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rap GTPase Activity Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Positive Regulation Of Protein Metabolic Process Phosphorylation Regulation Of Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Rap Protein Signal Transduction Regulation Of Exocytosis Positive Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Endothelial Barrier Protein Localization To Chromosome Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Kinase Activity	Regulation Of Cellular Component Organization Mitotic Cell Cycle Cell Cycle Process Cell Cycle Mitotic Cell Cycle Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Programmed Cell Death Intracellular MRNA Localization Positive Regulation Of Cell Death Regulation Of Organelle Organization Regulation Of Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Stress Granule Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Mitochondrion Organization Regulation Of Small GTPase Mediated Signal Transduction Microtubule-based Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Protein Tetramerization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Antigen Processing And Presentation Regulation Of Ras GTPase Activity Viral Process Mitotic Nuclear Division Intracellular Transport Of Virus Response To Metal Ion Positive Regulation Of Apoptotic Process Regulation Of Cell Growth Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction DNA Damage Checkpoint Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Programmed Cell Death Ribonucleoprotein Complex Assembly Negative Regulation Of Phosphorylation
Tagcloud ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1	10q24 17p13 cgh cnvs congenital deletions dlx5 duplications eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions shfm shfm1 split syndromic telomeric tp63 unrelated
Tagcloud (Difference) ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1	10q24 17p13 cgh cnvs congenital deletions dlx5 duplications eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions shfm shfm1 split syndromic telomeric tp63 unrelated
Tagcloud (Intersection) ?