LCOR and GUK1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	GUK1
Description		ligand dependent nuclear receptor corepressor	guanylate kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Nucleotide Binding GMP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Purine Nucleotide Metabolic Process DGDP Biosynthetic Process Xenobiotic Metabolic Process Nucleobase-containing Small Molecule Interconversion GDP-mannose Metabolic Process Glycoprotein Transport GMP Metabolic Process DGMP Metabolic Process DATP Metabolic Process GDP Biosynthetic Process
Pathways			Interconversion of nucleotide di- and triphosphates Azathioprine ADME
Drugs			Guanosine-5'-Monophosphate
Diseases
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Coronary artery disease ( 29212778)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	4 interacting genes: HNRNPD LCOR NLGN3 VHL
Entrez ID		84458	2987
HPRD ID		07609	00755
Ensembl ID		ENSG00000196233	ENSG00000143774
Uniprot IDs		Q96JN0	Q16774 Q6IBG8
PDB IDs		2COB 6V3X 6V3Y	6NUI 8PTS
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Cellular Response To Estradiol Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Response To Estradiol Histone Deacetylase Binding Circadian Regulation Of Translation Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Elongation Factor Activity Establishment Of Mitotic Sister Chromatid Cohesion Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Cohesin Complex Asymmetric, Glutamatergic, Excitatory Synapse Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Glutamate Receptor Signaling Pathway Neurexin Family Protein Binding Presynapse Assembly Cellular Response To Nitric Oxide Negative Regulation Of Catabolic Process Regulation Of Telomere Capping Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Histone Methyltransferase Binding Negative Regulation Of RNA Metabolic Process Cellular Response To Reactive Nitrogen Species Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Response To Nitric Oxide Response To Ether Regulation Of Cellular Response To Hypoxia Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
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