RAP1GAP and RAP1A

Number of citations: 0 (PubMedID 12842888)
Data Source: BioGRID (enzymatic study)

		RAP1GAP	RAP1A
Name		RAP1 GTPase activating protein	RAP1A, member of RAS oncogene family
Structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Early Endosome Golgi Apparatus Cytosol Membrane Axon Dendrite Neuronal Cell Body	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Sperm Midpiece Presynapse Glutamatergic Synapse
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity Small GTPase Binding Protein Homodimerization Activity	Nucleotide Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Protein-containing Complex Binding
	Biological Process	Adaptive Immune Response Phagocytosis Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Cell-cell Adhesion Negative Regulation Of Microvillus Assembly Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Response To Carbohydrate Positive Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of D-glucose Import Positive Regulation Of Phagocytosis Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis
Pathways		Rap1 signalling RET signaling	Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants Signaling by RAF1 mutants
GWAS		Abdominal aortic calcification levels ( 31659325 ) Heel bone mineral density ( 30598549 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 ) Immature fraction of reticulocytes ( 27863252 ) Liver enzyme levels ( 18940312 ) Mean reticulocyte volume ( 32888494 ) Metabolite levels ( 23823483 ) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399 ) Serum alkaline phosphatase levels ( 31666285 )	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Crohn's disease ( 30500874 32581322 ) High altitude adaptation ( 28373541 ) Lymphocyte count ( 32888494 ) Osteoporosis-related phenotypes ( 20548944 )
Novel Interactors		1 novel interactors: SDHB	None recorded
Interacting Genes		18 interacting genes: AFDN BRAF CDK1 CSNK1G2 DSCR9 DYNC1I1 GNAZ LCOR MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A VPS26C ZBTB12	43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C
Entrez ID		5909	5906
HPRD ID		02609	01545
Ensembl ID		ENSG00000076864	ENSG00000116473
Uniprot IDs		P47736 X6R8W7	A8KAH9 P62834
PDB IDs		1SRQ 3BRW	1C1Y 1GUA 3KUC 4KVG
GO Terms Enriched among Interactors		Protein Phosphorylation Phosphorylation Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Negative Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Exocytosis Kinase Activity Phosphate-containing Compound Metabolic Process Mitotic Nuclear Membrane Disassembly Regulation Of Neurotransmitter Secretion Nuclear Membrane Disassembly Membrane Disassembly Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Protein Localization Protein Localization To Site Of Double-strand Break Regulation Of Secretion Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Secretion By Cell Postsynaptic Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Positive Regulation Of Protein Modification Process Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Exocytosis Establishment Of Endothelial Barrier Chromosome Condensation Negative Regulation Of Secretion Positive Regulation Of D-glucose Transmembrane Transport Pronuclear Fusion Spindle Microtubule Endothelial Cell Development Peptidyl-serine Phosphorylation Regulation Of Exocytosis Protein Modification Process Nuclear Membrane Organization Centrosome Cycle Sperm Midpiece Presynapse Intracellular Signal Transduction Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Phosphorylation Modulation Of Chemical Synaptic Transmission MAPK Cascade ERK1 And ERK2 Cascade Positive Regulation Of Stress Fiber Assembly	GTPase Regulator Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Guanyl-nucleotide Exchange Factor Activity Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of GTPase Activity Plasma Membrane Establishment Of Endothelial Barrier Endothelial Cell Development Positive Regulation Of GTPase Activity CD95 Death-inducing Signaling Complex Positive Regulation Of Hydrolase Activity Neurotrophin Signaling Pathway Epithelial Cell Development Rap Protein Signal Transduction Regulation Of Microvillus Assembly GTPase Binding Regulation Of Signal Transduction Regulation Of Apoptotic Process Cytosol Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Communication Regulation Of Signaling Small GTPase Binding Nerve Growth Factor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Death-inducing Signaling Complex Assembly Diacylglycerol Binding Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling CAMP Binding Fas Signaling Pathway Protein-containing Complex Organization Cytoplasm Positive Regulation Of Cellular Component Biogenesis Regulation Of Developmental Process Protein-containing Complex Assembly GTPase Activator Activity Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Nucleosome Array Spacer Activity Positive Regulation Of Microvillus Assembly Regulation Of Cell Differentiation