LCOR and MLST8

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	MLST8
Description		ligand dependent nuclear receptor corepressor	MTOR associated protein MLST8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane TORC1 Complex TORC2 Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Protein Binding Protein-macromolecule Adaptor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	DNA Damage Response Cytoskeleton Organization Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization TORC1 Signaling TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycolytic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hypoxia Cellular Response To Osmotic Stress Positive Regulation Of Pentose-phosphate Shunt
Pathways			PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Height ( 28552196)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	13 interacting genes: A2M APPL2 ATXN1 CDK1 CDK2 EIF4EBP1 KEAP1 LCOR MAPKAP1 MTOR PRMT1 RPS6KA3 RPTOR
Entrez ID		84458	64223
HPRD ID		07609	17031
Ensembl ID		ENSG00000196233	ENSG00000167965
Uniprot IDs		Q96JN0	H3BPT1 Q9BVC4
PDB IDs		2COB 6V3X 6V3Y	4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5H64 5WBU 5WBY 5ZCS 6BCU 6BCX 6SB0 6SB2 6ZWM 6ZWO 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7TZO 7UXC 7UXH 8ERA 8RCH 8RCK 9F44 9F45
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	TOR Signaling Negative Regulation Of Translational Initiation TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Serine/threonine Protein Kinase Complex Positive Regulation Of Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Cellular Response To Oxygen-containing Compound Cyclin-dependent Protein Kinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Pentose-phosphate Shunt Regulation Of Cell Differentiation Positive Regulation Of Cell Growth Negative Regulation Of Cellular Response To Insulin Stimulus Histone Kinase Activity TORC1 Complex Regulation Of Pentose-phosphate Shunt Cellular Response To Methionine Negative Regulation Of Translation Regulation Of Translation Intracellular Signal Transduction Response To Methionine Regulation Of NADP Metabolic Process Positive Regulation Of TORC1 Signaling TORC2 Complex Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression G1/S Transition Of Mitotic Cell Cycle Regulation Of Multicellular Organismal Development Cellular Response To Amino Acid Stimulus Cell Cycle G1/S Phase Transition Cellular Response To Nutrient Levels Regulation Of Macromolecule Biosynthetic Process Cellular Response To L-leucine Positive Regulation Of TOR Signaling Cellular Response To Chemical Stress Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Regulation Of Growth Post-transcriptional Regulation Of Gene Expression TORC2 Signaling Response To L-leucine Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase III Enzyme-substrate Adaptor Activity
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