LCOR and GM2A

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	GM2A
Description		ligand dependent nuclear receptor corepressor	ganglioside GM2 activator
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Region Lysosome Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Beta-N-acetylhexosaminidase Activity Lipid Transporter Activity Protein Binding Enzyme Activator Activity Phospholipase Activator Activity Hydrolase Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Ganglioside Metabolic Process Lipid Metabolic Process Sphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Glycosphingolipid Catabolic Process Nervous System Process Neuromuscular Process Controlling Balance
Pathways			Neutrophil degranulation Glycosphingolipid catabolism
Drugs			Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid
Diseases			GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	4 interacting genes: GPLD1 HEXA LCOR PLD2
Entrez ID		84458	2760
HPRD ID		07609	02034
Ensembl ID		ENSG00000196233	ENSG00000196743
Uniprot IDs		Q96JN0	P17900
PDB IDs		2COB 6V3X 6V3Y	1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Phospholipase D Activity Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity Filopodium Tip Optic Nerve Morphogenesis Phosphate-containing Compound Metabolic Process Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Detection Of Temperature Stimulus Negative Regulation Of Skeletal Muscle Cell Proliferation Cell Migration In Hindbrain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Skeletal Muscle Cell Differentiation Axon Guidance Receptor Activity Negative Regulation Of Satellite Cell Differentiation Immunological Synapse Formation Detection Of Temperature Stimulus Involved In Sensory Perception Cranial Nerve Morphogenesis Hindbrain Tangential Cell Migration Dendritic Spine Development Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Retinal Ganglion Cell Axon Guidance Dendritic Spine Morphogenesis Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Activity Skeletal Muscle Satellite Cell Activation Lipid Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Sterol Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Phosphatase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Glycerophospholipid Metabolic Process Regulation Of Dephosphorylation Negative Regulation Of Triglyceride Catabolic Process Phospholipid Metabolic Process Response To Triglyceride Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Triglyceride Metabolic Process Hematopoietic Stem Cell Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Triglyceride Biosynthetic Process Cellular Response To Triglyceride Positive Regulation Of Dephosphorylation Immune Response-activating Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Clearance Activation Of Immune Response
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