RAP1GAP and MEX3B

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RAP1GAP	MEX3B
Gene Name		RAP1 GTPase activating protein	mex-3 RNA binding family member B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Membrane	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Ras GTPase Binding Protein Homodimerization Activity Rap GTPase Activator Activity	Calcium Ion Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Signal Transduction Metabolic Process Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity Negative Regulation Of Microvillus Assembly	Protein Phosphorylation Protein Autophosphorylation
Pathways		Rap1 signalling Adaptive Immune System
Drugs
Diseases
GWAS		Liver enzyme levels ( 18940312)
Protein-Protein Interactions		15 interactors: BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B MLLT4 PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12	6 interactors: ATP13A2 NUDT3 RAP1GAP SMAD4 SNUPN UBE2D3
Entrez ID		5909	84206
HPRD ID		02609	15256
Ensembl ID		ENSG00000076864	ENSG00000183496
Uniprot IDs		P47736	Q6ZN04
PDB IDs		1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Catalytic Activity Mitotic Nuclear Envelope Disassembly Regulation Of Synaptic Vesicle Transport Nuclear Envelope Disassembly Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Neurotransmitter Secretion Activation Of MAPKK Activity Nuclear Envelope Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rap GTPase Activity Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Positive Regulation Of Protein Metabolic Process Phosphorylation Regulation Of Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Rap Protein Signal Transduction Regulation Of Exocytosis Positive Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Endothelial Barrier Protein Localization To Chromosome Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Kinase Activity	BMP Signaling Pathway Diphosphoinositol Polyphosphate Catabolic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis SnRNA Import Into Nucleus Diadenosine Polyphosphate Catabolic Process Negative Regulation Of Microvillus Assembly RNA Import Into Nucleus Nephrogenic Mesenchyme Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Manganese Ion DNA-templated Transcription, Initiation Regulation Of Microvillus Assembly Endocardial Cell Differentiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Endothelial Cell Activation Response To Hypoxia Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Brainstem Development SMAD Protein Complex Assembly Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Canal Development Regulation Of Hair Follicle Development Heart Valve Formation Metanephric Mesenchyme Development Endocardial Cushion Formation Endocardium Development Atrioventricular Valve Morphogenesis Positive Regulation Of Rap GTPase Activity Response To Manganese Ion Regulation Of Hair Cycle Endocardial Cushion Morphogenesis Atrioventricular Valve Development Regulation Of Rap GTPase Activity Protein K11-linked Ubiquitination Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Rap Protein Signal Transduction
Tagcloud ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Difference) ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Intersection) ?