RAP1GAP and MEX3B

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RAP1GAP	MEX3B
Description		RAP1 GTPase activating protein	mex-3 RNA binding family member B
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Early Endosome Golgi Apparatus Cytosol Membrane Axon Dendrite Neuronal Cell Body	P-body Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity Small GTPase Binding Protein Homodimerization Activity	Nucleic Acid Binding RNA Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Adaptive Immune Response Phagocytosis Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Cell-cell Adhesion Negative Regulation Of Microvillus Assembly Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor	Protein Phosphorylation Protein Autophosphorylation
Pathways		Rap1 signalling RET signaling
Drugs
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)	Height ( 31562340) Macular thickness ( 30535121) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Post-traumatic stress disorder ( 24677629) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tourette syndrome ( 30818990)
Interacting Genes		18 interacting genes: AFDN BRAF CDK1 CSNK1G2 DSCR9 DYNC1I1 GNAZ LCOR MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A VPS26C ZBTB12	9 interacting genes: ATP13A2 CFLAR LINC00839 NUDT3 RAP1GAP SMAD4 SNUPN UBE2D3 USP7
Entrez ID		5909	84206
HPRD ID		02609	15256
Ensembl ID		ENSG00000076864	ENSG00000183496
Uniprot IDs		P47736 X6R8W7	Q6ZN04
PDB IDs		1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Protein Phosphorylation Phosphorylation Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Negative Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Exocytosis Kinase Activity Phosphate-containing Compound Metabolic Process Mitotic Nuclear Membrane Disassembly Regulation Of Neurotransmitter Secretion Nuclear Membrane Disassembly Membrane Disassembly Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Protein Localization Protein Localization To Site Of Double-strand Break Regulation Of Secretion Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Secretion By Cell Postsynaptic Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Positive Regulation Of Protein Modification Process Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Exocytosis Establishment Of Endothelial Barrier Chromosome Condensation Negative Regulation Of Secretion Positive Regulation Of D-glucose Transmembrane Transport Pronuclear Fusion Spindle Microtubule Endothelial Cell Development Peptidyl-serine Phosphorylation Regulation Of Exocytosis Protein Modification Process Nuclear Membrane Organization Centrosome Cycle Sperm Midpiece Presynapse Intracellular Signal Transduction Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Phosphorylation Modulation Of Chemical Synaptic Transmission MAPK Cascade ERK1 And ERK2 Cascade Positive Regulation Of Stress Fiber Assembly	Regulation Of Extracellular Matrix Organization Positive Regulation Of Extracellular Matrix Organization Response To Growth Factor Intracellular Iron Ion Homeostasis Response To Decreased Oxygen Levels Cellular Response To Growth Factor Stimulus Negative Regulation Of Cardiac Myofibril Assembly Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Hypoxia Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Negative Regulation Of Microvillus Assembly Cysteine-type Endopeptidase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Manganese Ion Binding Diphosphoinositol Polyphosphate Catabolic Process Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Response To Oxygen Levels Gonad Morphogenesis Regulation Of Protein Catabolic Process Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Glial Cell Derived Neurotrophic Factor Cellular Response To Stress Skeletal Myofibril Assembly SnRNA Import Into Nucleus 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol Phosphate Catabolic Process Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Autophagosome Organization Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Myoblast Fusion Cellular Response To Insulin Stimulus Diphosphoinositol Polyphosphate Metabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process
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